Ovarian Cancer Rx Promising for Prostate Tumors

This article originally appeared here.
Share this content:
Ovarian Cancer Rx Promising for Prostate Tumors
Ovarian Cancer Rx Promising for Prostate Tumors

THURSDAY, Oct. 29, 2015 (HealthDay News) -- Lynparza (olaparib) targets mutations found in about 30 percent of men with prostate cancer, but may also benefit men whose tumors have acquired defects in DNA repair, according to research published in the Oct. 29 issue of the New England Journal of Medicine.

For the study, 49 men with advanced prostate cancer who were no longer responding to standard therapies received olaparib. Of these, 16 (33 percent) responded to the drug. In these 16 patients, next-generation sequencing identified homozygous deletions, deleterious mutations, or both in DNA-repair genes.

The researchers also found that in the men who responded to the drug, olaparib appeared to halt prostate cancer growth and was associated with lasting reductions in prostate-specific antigen levels. The drug was also associated with reductions in tumor cells in the blood and a decrease in tumor size seen on computed tomography and magnetic resonance imaging.

"We observed that about a third of the patients had a response in the tumor, normally lasting over six months and many times over a year," lead researcher Joaquin Mateo, M.D., a medical oncologist at the Institute of Cancer Research in London, told HealthDay. Only two of the 33 patients who did not respond to the drug had these genetic changes, he said. "Therefore, we believe we have found a way to predict which patients are likely to respond to this new therapy."

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Bayer Stops U.S. Sale of Essure Birth Control Implant

Bayer Stops U.S. Sale of Essure Birth Control ...

Problems with device include chronic pain and perforations of the uterus and fallopian tubes

C.S. Mott Poll Addresses Child Safety at Amusement Parks

C.S. Mott Poll Addresses Child Safety at Amusement ...

2016 saw U.S. emergency departments deal with 30,000 injuries linked to amusement parks, carnivals

Greening Vacant Land Improves Neighborhood Mental Health

Greening Vacant Land Improves Neighborhood Mental Health

Cleaning up vacant lots in resource-limited urban settings can aid residents' mental health

is free, fast, and customized just for you!




Already a member?

Sign In Now »