ORBIT Bleeding Risk Score Performs Best in A-Fib

This article originally appeared here.
Share this content:
ORBIT Bleeding Risk Score Performs Best in A-Fib
ORBIT Bleeding Risk Score Performs Best in A-Fib

FRIDAY, Dec. 8, 2017 (HealthDay News) -- Four contemporary clinical bleeding risk scores are able to identify atrial fibrillation (AF) patients at risk for major bleeding and life-threatening bleeding, according to a study published online Nov. 7 in the Journal of Internal Medicine.

Marco Proietti, M.D., from the Sapienza University of Rome, and colleagues compared the performance of contemporary clinical bleeding risk scores (HAS-BLED, ORBIT, ATRIA, and HEMORR2HAGES) in 18,113 patients with AF randomized to dabigatran (110 or 150 mg) or warfarin in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial.

The researchers found that over a median follow-up of 2.0 years, there were 1,182 major bleeding events. For all the four risk scores, high-risk subgroups had higher risk of major bleeding (all P < 0.001). The ORBIT score showed the best discrimination for major, life-threatening, and intracranial bleeding, which were significantly better than for the HAS-BLED score (all P < 0.05). For dabigatran 150 mg twice a day versus warfarin, there were significant treatment interactions between the bleeding scores and the risk of major bleeding with the ORBIT (P = 0.0019), ATRIA (P < 0.001), and HEMORR2HAGES (P < 0.001) scores, while the HAS-BLED score showed a non-significant trend for interaction (P = 0.0607).

"Among the current clinical bleeding risk scores, the ORBIT score demonstrated the best discrimination and calibration," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Boehringer Ingelheim, which funded the RE-LY trial.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »