Oral Bisphosphonate Use Cuts Risk of Post-Implant Revision Sx

This article originally appeared here.
Share this content:
Oral Bisphosphonate Use Cuts Risk of Post-Implant Revision Sx
Oral Bisphosphonate Use Cuts Risk of Post-Implant Revision Sx

(HealthDay News) -- For patients undergoing total joint replacement, oral bisphosphonate use is associated with a reduction in the risk of revision surgery, according to a study published in the November issue of Arthritis & Rheumatology.

Daniel Prieto-Alhambra, M.D., Ph.D., from the University of Oxford in the United Kingdom, and colleagues conducted a retrospective cohort study within Danish nationwide registries to examine the correlation between bisphosphonate use and implant survival. Patients aged 40 years or older undergoing total joint replacement between 1998 and 2007 were identified. Each of 1,558 bisphosphonate users was matched, using propensity scores, to up to six bisphosphonate nonusers (n = 8,966).

The researchers found that during the follow-up period, 1.73 percent of bisphosphonate users and 4.45 percent of matched nonusers underwent revision surgery, at a median of 2.61 years after first surgery. Bisphosphonate users had a reduced risk of revision surgery (hazard ratio, 0.41). Patients with the longest duration of treatment and/or the best adherence had the strongest correlation.

"Oral bisphosphonate users have a 59 percent reduced risk of revision surgery," the authors write. "This association is only present when bisphosphonates are started after arthroplasty surgery."

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves First Generic EpiPen

FDA Approves First Generic EpiPen

Approval will address both rising costs and shortages of epinephrine

Report Details Corneal Infection Tied to Sleeping in Contacts

Report Details Corneal Infection Tied to Sleeping in ...

Six patients reported sleeping in lenses on regular basis; most had vision loss, permanent damage

Honey May Protect Children Who Swallow Button Batteries

Honey May Protect Children Who Swallow Button Batteries

Honey and Carafate appear to rapidly protect against batteries' caustic effects

is free, fast, and customized just for you!




Already a member?

Sign In Now »