NT-proBNP Improves Heart Failure Prediction in T2DM

Share this content:
NT-proBNP Improves Heart Failure Prediction in T2DM
NT-proBNP Improves Heart Failure Prediction in T2DM

TUESDAY, July 18, 2017 (HealthDay News) -- For patients with type 2 diabetes, N-terminal pro-B-type natriuretic peptide (NT-proBNP) improves prediction of heart failure, according to a study published online July 6 in Diabetes Care.

Toshiaki Ohkuma, from the University of Sydney, and colleagues conducted a nested case-cohort study of 3,098 participants with type 2 diabetes. The authors examined the individual and combined effect of NT-proBNP, high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) on the prediction of heart failure incidence or progression.

The researchers found that after adjustment for major risk factors, a higher value of each biomarker was significantly associated with increased risk of heart failure incidence or progression, with hazard ratios of 3.06, 1.50, 1.48, and 1.32 for NT-proBNP, hs-cTnT, IL-6, and hs-CRP, respectively. There was a meaningful improvement in five-year risk-predictive performance with the addition of NT-proBNP to the model that included conventional risk factors (C-statistic, 0.8162 to 0.8800; continuous net reclassification improvement, 73.1 percent). There was no improvement in prediction metrics with the addition of hs-cTnT, IL-6, or hs-CRP in combination or when added to NT-proBNP.

"Only NT-proBNP strongly and consistently improved the prediction of heart failure in patients with type 2 diabetes beyond a wide range of clinical risk factors and biomarkers," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »