Novel Biomarkers Identified for Prostate Cancer in Non-Blacks

This article originally appeared here.
Share this content:
Novel Biomarkers Identified for Prostate Cancer in Non-Blacks
Novel Biomarkers Identified for Prostate Cancer in Non-Blacks

MONDAY, June 19, 2017 (HealthDay News) -- Novel biomarkers have been identified that may have utility for predicting prostate cancer in non-African-American men, according to a study published in the July issue of The Journal of Urology.

Padraic G. O'Malley, M.D., from the Weill Cornell Medical College in New York City, and colleagues examined the utility of urinary biomarkers added to clinical risk calculators for predicting prostate cancer in a cohort of 718 men who were part of the Early Detection Research Network (72 African-American men).

The researchers found that when combined with the Prostate Cancer Prevention Trial Risk Calculator, prostate cancer antigen 3 (PCA3) and transmembrane protease serine 2 and v-ets erythroblastosis virus E26 oncogene homolog gene fusion (T2ERG) added utility for the prediction of prostate cancer and clinically-significant prostate cancer. This utility was only seen in non-African-American men, with significant increases in the area under the curve values for prostate cancer and clinically-significant prostate cancer for PCA3 (0.64 to 0.75 and 0.69 to 0.77, respectively) and T2ERG (0.64 to 0.74 and 0.69 to 0.73, respectively). No added benefit was seen with the addition of biomarkers for African-American men.

"As novel biomarkers are discovered, clinical utility should be established across demographically diverse cohorts," the authors write.

Two authors disclosed financial ties to the biopharmaceutical industry.

Abstract
Full Text
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »