Non-Invasive Test Can Detect Urothelial Cancer

Share this content:
Non-Invasive Test Can Detect Urothelial Cancer
Non-Invasive Test Can Detect Urothelial Cancer

THURSDAY, March 29, 2018 (HealthDay News) -- UroSEEK, which uses DNA recovered from cells shed into urine, can detect urothelial cancer, according to a study published online March 20 in eLife.

Simeon U. Springer, from the Ludwig Center for Cancer Genetics and Therapeutics in Baltimore, and colleagues developed a test to detect urothelial neoplasms that incorporates massive parallel sequencing assays for mutations in 11 genes and copy number changes on 39 chromosome arms. UroSEEK was used in 570 patients at risk for bladder cancer (BC) and 56 with upper tract urothelial cancer.

The researchers found that UroSEEK was positive in 83 percent of those who developed BC. Combined with cytology, it detected 95 percent of patients who developed BC. Seventy-five percent of patients with upper tract urothelial cancer tested positive by UroSEEK, including 79 percent of those with non-invasive tumors. In 68 percent of urines obtained from BC patients under surveillance who demonstrated clinical evidence of recurrence, UroSEEK detected genetic abnormalities. In low-grade BCs, UroSEEK detected 67 percent of cases, while none were detected by cytology.

"These results establish the foundation for a new non-invasive approach for detection of urothelial cancer," the authors write.

Several authors disclosed financial ties to Personal Genome Diagnostics, PapGene, and Sysmex-Inostics.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »