Non-HIV-Related Kaposi Sarcoma in BRAFi-Treated Patient

This article originally appeared here.
Share this content:
Non-HIV-Related Kaposi Sarcoma in BRAFi-Treated Patient
Non-HIV-Related Kaposi Sarcoma in BRAFi-Treated Patient

THURSDAY, March 17, 2016 (HealthDay News) -- In a case report published online Feb. 28 in the Journal of Clinical Pharmacy and Therapeutics, researchers document non-HIV-associated Kaposi sarcoma in a male patient with myasthenia gravis and metastatic melanoma treated with the BRAF inhibitor dabrafenib.

Sagun Parakh, M.B.Ch.B., from Austin Health in Heidelberg, Australia, and colleagues describe a case of extensive bilateral pedal Kaposi sarcoma in a patient treated with dabrafenib for metastatic melanoma. The 76-year-old, HIV-negative, male patient, without diabetes, with a history of myasthenia gravis and metastatic melanoma presented with enlarging macular/plaque-like rash on his feet. The rash was preceded by bilateral plantar shooting pains.

The authors initially thought that the rash was due to initiation of the BRAF inhibitor dabrafenib, as rash progression was in the context of acute-on-chronic immunosuppression. Kaposi sarcoma was revealed in histopathologic findings from skin biopsies. The patient continued on dabrafenib and was treated with superficial radiotherapy to the feet, which resulted in prompt pain relief and arrest of further spread of Kaposi sarcoma.

"This case illustrates the diagnostic pitfalls in patients treated with targeted therapies and highlights the importance of broad differentials for unusual presentations and early biopsy," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »