Nodal Metastasis Risk Up When Cancer Is Directly on the Lip

Share this content:
Nodal Metastasis Risk Up When Cancer Is Directly on the Lip
Nodal Metastasis Risk Up When Cancer Is Directly on the Lip

THURSDAY, May 10, 2018 (HealthDay News) -- The risk of nodal metastasis is five-fold greater for skin cancer on the vermilion lip versus the cutaneous lip, according to a study published online May 2 in JAMA Dermatology.

David M. Wang, from Case Western Reserve University in Cleveland, and colleagues compared differences in risks of recurrence, metastasis, and death from cutaneous squamous cell carcinoma (cSCC) on the vermilion versus cutaneous lip among 303 patients with 310 primary cSCCs of the lip (138 cutaneous and 172 vermilion) diagnosed between 2000 and 2015 at two academic tertiary care centers.

The researchers found that outcomes for vermilion versus cutaneous locations were as follows: local recurrence, 6.4 percent (11 of 172) versus 2.9 percent (four of 138); nodal metastasis, 7.6 percent (13 of 172) versus 1.5 percent (two of 138); distant metastasis, 0.6 percent (one of 172) versus 0.7 percent (one of 138); disease-specific death, 3.5 percent (six of 172) versus 2.9 percent (four of 138); and all-cause death, 26.7 percent (46 of 172) versus 29.0 percent (40 of 138). Only the difference for nodal metastasis was statistically significant (P = 0.01). In multivariable analysis, nodal metastasis was associated with vermilion lip location (subhazard ratio, 5.0) and invasion beyond fat (fascia or beyond for vermilion lip) (subhazard ratio, 4.4).

"Vermilion involvement may merit radiologic nodal staging and inclusion in future tumor staging, since it was independently associated with higher-risk cSCC of the lip region," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Zika, West Nile Cases Reported in Alabama

Zika, West Nile Cases Reported in Alabama

State health officials note that Zika hasn't been transmitted locally

TBI Linked to Increased Suicide Risk

TBI Linked to Increased Suicide Risk

Increased suicide risk with one, two, and three or more medical contacts for traumatic brain injury

Triple Combo Blood Pressure Pill Can Improve BP Control

Triple Combo Blood Pressure Pill Can Improve BP ...

Proportion achieving target BP increased with use of triple combo pill versus usual care at six months

is free, fast, and customized just for you!




Already a member?

Sign In Now »