No Response to First Antifungals Tied to Worse Keratitis Outcomes

This article originally appeared here.
Share this content:
No Response to First Antifungals Tied to Worse Keratitis Outcomes
No Response to First Antifungals Tied to Worse Keratitis Outcomes

MONDAY, July 11, 2016 (HealthDay News) -- Fungal keratitis patients pretreated with antifungal medication appear to have worse outcomes, according to a study published online June 21 in Clinical & Experimental Ophthalmology.

Catherine Q. Sun, M.D., from the University of California, San Francisco, and colleagues conducted a randomized , double-blind trial to determine the optimal treatment for filamentous fungal keratitis. Patients at the Aravind Eye Care System in India were randomized to treatment with either topical natamycin or voriconazole.

The researchers found that 44 percent of the 323 patients enrolled presented on an antifungal agent. Larger mean baseline infiltrate size and epithelial defect size were seen in pretreated patients. Pretreatment was associated with significantly worse three-month visual acuity, larger three-month scar size, and increased odds of corneal perforation and/or transplant in multivariate analysis.

"Fungal keratitis that is smear-positive despite being pretreated with appropriate antifungal agents appears to be a risk factor for worse outcomes, likely due to initial ulcer severity and treatment failure," conclude the authors.

The drugs used in the study were donated by Alcon and Pfizer.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ground Beef Recalled After E. Coli Outbreak

Ground Beef Recalled After <i>E. Coli</i> Outbreak

Beef was produced and packaged at Cargill Meat Solutions in Fort Morgan, Colo.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

Alzheimer's disease and related dementias burden is expected to increase to 3.3 percent in 2060

Long-Term Outcomes of Breast Implants Explored

Long-Term Outcomes of Breast Implants Explored

Higher rates of Sjogren syndrome, scleroderma, RA, stillbirth, melanoma for silicone implants

is free, fast, and customized just for you!




Already a member?

Sign In Now »