Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

This article originally appeared here.
Share this content:
Next-Generation Sequencing May Improve Pediatric Epilepsy Tx
Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

FRIDAY, June 29, 2018 (HealthDay News) -- Next-generation sequencing (NGS) can improve treatment efficacy and reduce hospitalization in children with drug-resistant epilepsy (DRE), according to a study published online June 22 in CNS Neuroscience & Therapeutics.

Jing Peng, Ph.D., from Central South University in China, and colleagues conducted genetic testing on 273 pediatric DRE patients with no obvious acquired etiology; 74 underwent whole-exome sequencing (WES), 141 had epilepsy-related gene panel testing, and 58 had clinical WES gene panel testing. Frequency of seizures, outpatient visits, and hospitalization was also assessed.

The researchers found that a genetic diagnosis was made in 86 patients (31.5 percent; 93 likely disease-causing mutations in 33 genes). By testing type, detection rates were 32.6 percent for the epilepsy-related gene panel,44.8 percent for the clinical WES gene panel, and 17.3 percent for WES. Also, 34 patients accepted therapy based on their mutant genes, after which 52.9 percent became seizure-free and 38.2 percent experienced seizure reduction. Hospitalization incidents were significantly lower for patients after testing than before regardless of positive or negative genetic results.

"These results offer further proof that NGS approaches represent powerful tools for establishing a definitive diagnosis," conclude the authors.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Many Americans May Have Prediabetes and Not Know It

CDC: Many Americans May Have Prediabetes and Not ...

AMA, CDC launch a campaign to raise awareness about prediabetes

Low-Carbohydrate Diets Linked to Increase in Calories Burned

Low-Carbohydrate Diets Linked to Increase in Calories Burned

Total energy expenditure is greater for those on a low- or moderate-carb diet during weight-loss maintenance

Many Patients Do Not Engage Health Care Provider During MS Relapse

Many Patients Do Not Engage Health Care Provider ...

Only half of patients reported always engaging health care providers

is free, fast, and customized just for you!




Already a member?

Sign In Now »