New Technique Allows Rapid Bedside Measurement of GFR

This article originally appeared here.
Share this content:
New Technique Allows Rapid Bedside Measurement of GFR
New Technique Allows Rapid Bedside Measurement of GFR

FRIDAY, June 29, 2018 (HealthDay News) -- A visible fluorescent injectate (VFI)-based approach for direct measurement of glomerular filtration rate (mGFR) is accurate with high reproducibility, according to a study published in the June issue of the Journal of the American Society of Nephrology.

Dana V. Rizk, M.D., from the University of Alabama at Birmingham, and colleagues developed a new biomarker, VFI, consisting of a 150-kD rhodamine derivative and 5-kD fluorescein carboxymethylated dextrans. VFI-based mGFR values were compared with values obtained by measuring iohexol plasma disappearance in a study involving 16 adults with normal kidney function, eight with chronic kidney disease (CKD) stage 3, and eight with CKD stage 4. VFI-based mGFR required three blood draws over three hours, while five samples taken over six hours were required for iohexol-based mGFR. Repeat VFI injections at 24 hours were received by eight healthy participants.

The researchers found that in all participants, there were close linear correlations for VFI-based mGFR values with the iohexol-based mGFR values. The injections were tolerated well, even when they were given on consecutive days. There were no reports of serious adverse events. There was high reproducibility for VFI-based mGFR.

"The VFI-based approach allows for the rapid determination of mGFR at the bedside while maintaining patient safety and measurement accuracy and reproducibility," the authors write.

Several authors disclosed ties to FAST Biomedical; one author disclosed ties to TdB Consultancy, which collaborates with FAST BioMedical on dextran development. One author was employed by ICON Early Phase Services LLC.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »