New Risk Score Promising for Predicting MI, Death

Share this content:
New Risk Score Promising for Predicting MI, Death
New Risk Score Promising for Predicting MI, Death

THURSDAY, Sept. 13, 2018 (HealthDay News) -- A score based on the results of three laboratory tests has higher sensitivity and specificity than cardiac troponin alone for stratifying patients presenting with suspected acute coronary syndrome, according to a study published online Aug. 19 in CMAJ, the journal of the Canadian Medical Association.

Peter A. Kavsak, Ph.D., from McMaster University in Hamilton, Canada, and colleagues constructed a clinical chemistry score (CCS; range, 0 to 5 points) based on high-sensitivity cardiac troponin (hs-cTn), glucose level, and estimated glomerular filtration rate test results. The score was validated as a predictor of 30-day myocardial infarction (MI) or death using data from four cohorts involving 4,245 patients who presented to the emergency department with symptoms suggestive of acute coronary syndrome. A total of 17.1 percent of participants had an MI or died within 30 days.

The researchers found that low-risk patients were best identified with a CCS score of 0 points. High-sensitivity cardiac troponin I (hs-cTnI) CCS had a sensitivity of 100 percent, with 8.9 percent of the population classified as low risk of MI or death within 30 days; high-sensitivity cardiac troponin T (hs-cTnT) CCS had a sensitivity of 99.9 percent, with 10.5 percent of the population classified as low-risk. The CCS had better sensitivity than hs-cTn alone. High-risk patients were best identified with a CCS score of 5 points (hs-cTnI CCS: specificity, 96.6 percent with 11.2 percent of the population classified as high-risk; hs-cTnT CCS: specificity, 94 percent and 13.1 percent of the population classified as high risk) versus using the overall 99th percentiles for the hs-cTn assays (specificity of hs-cTnI, 93.2 percent; specificity of hs-cTnT, 73.8 percent).

"Adoption of the clinical chemistry score algorithm would standardize reporting of high-sensitivity cardiac troponin test results, how the tests are interpreted in the normal range, and represent an option less susceptible to both analytical and preanalytical errors," Kavsak said in a statement.

Several authors disclosed financial ties to pharmaceutical companies, including Abbott Laboratories and Roche Diagnostics, which provided reagent support for the study. Two authors have a pending patent application on a risk stratification score for patients with possible cardiac injury.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ground Beef Recalled After E. Coli Outbreak

Ground Beef Recalled After <i>E. Coli</i> Outbreak

Beef was produced and packaged at Cargill Meat Solutions in Fort Morgan, Colo.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

Alzheimer's disease and related dementias burden is expected to increase to 3.3 percent in 2060

Long-Term Outcomes of Breast Implants Explored

Long-Term Outcomes of Breast Implants Explored

Higher rates of Sjogren syndrome, scleroderma, RA, stillbirth, melanoma for silicone implants

is free, fast, and customized just for you!




Already a member?

Sign In Now »