New Compound May Help Reduce Side Effects From Levodopa

This article originally appeared here.
Share this content:
New Compound May Help Reduce Side Effects From Levodopa
New Compound May Help Reduce Side Effects From Levodopa

THURSDAY, Nov. 19, 2015 (HealthDay News) -- Animal studies have uncovered a compound that might reduce the adverse effects of levodopa. The research was published in the Nov. 18 issue of Neuron.

In the new study, an international team of researchers discovered that the brain neurons responsible for levodopa's side effects have a unique surface receptor that should normally help balance the effects of the drug.

When mice and monkeys with Parkinson-like diseases were given a new compound -- an M4 muscarinic receptor positive allosteric modulator -- that boosted the function of the receptor, there was a sharp drop in uncontrolled movement caused by levodopa.

"If clinical trials confirm our preliminary findings, the eventual drug developed could make a significant improvement in the quality of life for people with Parkinson's disease," lead researcher D. James Surmeier, Ph.D., chair of physiology at the Northwestern University Feinberg School of Medicine in Chicago, said in a university news release.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Study Provides Estimates of U.S. Prevalence of Type 1, 2 Diabetes

Study Provides Estimates of U.S. Prevalence of Type ...

Prevalence of type 1 diabetes 0.5 percent, type 2 diabetes 8.5 percent among U.S. adults

Black Individuals at Highest Risk of Legal Intervention Injury

Black Individuals at Highest Risk of Legal Intervention ...

Increase in rates of injuries from 2005 to 2009, followed by a drop to 2015, returning to ~2005 levels

Research Links Doctor Burnout to Patient Safety Incidents

Research Links Doctor Burnout to Patient Safety Incidents

Physician burnout linked to increased risk of patient safety incidents, reduced patient satisfaction

is free, fast, and customized just for you!




Already a member?

Sign In Now »