Neratinib Not Superior to Trastuzumab in ERBB2-Breast CA

This article originally appeared here.
Share this content:
Neratinib Not Superior to Trastuzumab in ERBB2-Breast CA
Neratinib Not Superior to Trastuzumab in ERBB2-Breast CA

FRIDAY, April 15, 2016 (HealthDay News) -- Neratinib-paclitaxel is no better than trastuzumab-paclitaxel for progression-free survival in recurrent and/or metastatic ERBB2-positive breast cancer, although it may delay the onset and reduce the frequency of central nervous system progression, according to a study published online April 14 in JAMA Oncology.

Ahmad Awada, M.D., Ph.D., from the Université Libre de Bruxelles in Belgium, and colleagues conducted a randomized open-label trial at 188 centers in 34 countries involving 479 women with previously untreated recurrent and/or metastatic ERBB2-positive breast cancer. Participants were randomized to neratinib-paclitaxel or trastuzumab-paclitaxel (242 and 237, respectively). Randomization was stratified by prior trastuzumab and lapatinib exposure, hormone-receptor status, and region.

The researchers found that the median progression-free survival was 12.9 months with both neratinib-paclitaxel and trastuzumab-paclitaxel (hazard ratio, 1.02; 95 percent confidence interval, 0.81 to 1.27). The incidence of central nervous system recurrences was lower with neratinib-paclitaxel (relative risk, 0.48; 95 percent confidence interval, 0.29 to 0.79), and time to central nervous system metastases delayed (hazard ratio, 0.45; 95 percent confidence interval, 0.26 to 0.78). Common grade 3 to 4 adverse events included diarrhea, neutropenia, and leukopenia; there was no grade 4 diarrhea.

"In spite of similar overall efficacy, neratinib-paclitaxel may delay the onset and reduce the frequency of central nervous system progression, a finding that requires a larger study to confirm," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Wyeth, Pfizer, and Puma Biotechnology (manufacturer of neratinib), all of which funded the study.

Abstract
Full Text
Editorial

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

WHO: Vaccine Hesitancy a Major Global Health Threat

WHO: Vaccine Hesitancy a Major Global Health Threat

Percentage of U.S. children 19 to 35 months who have not been vaccinated has quadrupled since 2001

FDA Down to 5 Weeks of Funding to Review New Drug Applications

FDA Down to 5 Weeks of Funding to ...

Agency cannot accept new fees or applications until the shutdown is over

FDA Approves First Generic Version of Epilepsy Drug Sabril

FDA Approves First Generic Version of Epilepsy Drug ...

Generic equivalents held to same vigorous manufacturing standards as brand-name drugs

is free, fast, and customized just for you!




Already a member?

Sign In Now »