Negative Fateful Life Events Linked to Advanced Brain Aging

Share this content:
Negative Fateful Life Events Linked to Advanced Brain Aging
Negative Fateful Life Events Linked to Advanced Brain Aging

THURSDAY, April 12, 2018 (HealthDay News) -- Negative fateful life events (FLEs) in midlife are associated with advanced predicted brain aging, according to a study published in the July issue of Neurobiology of Aging.

Sean N. Hatton, Ph.D., from the University of California in San Diego, and colleagues examined whether negative midlife FLEs are associated with advanced brain aging after controlling for physical, psychological, and lifestyle factors in a cohort of 359 men (mean age, 62 years) participating in the Vietnam Era twin study of aging. Participants were assessed for negative FLEs, health and well-being, general cognitive ability, socioeconomic status, depression, and ethnicity at two different time points. Participants underwent magnetic resonance imaging, and T1-weighted images were processed. To predict brain age, neuroanatomical measurements were entered into the Brain-Age Regression Analysis and Computation Utility software.

The researchers observed a correlation for having more midlife FLEs, especially relating to interpersonal relationships, with advanced predicted brain aging. After they controlled for the significant covariates of alcohol consumption, cardiovascular risk, adult socioeconomic status, and ethnicity, the correlation persisted.

"Individuals who had higher levels of major life events showed signs of advanced predicted brain aging," the authors write. "It remains to be determined whether the influence of midlife FLEs and other factors on brain age may change with increasing chronological age."

One author disclosed financial ties to CorTechs Laboratories.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Cap'n Crunch Cereal Recalled Due to Salmonella Scare

Cap'n Crunch Cereal Recalled Due to <i>Salmonella</i> Scare

No illnesses related to the products have been reported to date

FDA Approves First-Line Tx for Peripheral T-Cell Lymphoma

FDA Approves First-Line Tx for Peripheral T-Cell Lymphoma

Adcetris approved in combination with chemo to treat systemic anaplastic large cell lymphoma

FDA Warns Against Giving Honey-Filled Pacifiers to Infants

FDA Warns Against Giving Honey-Filled Pacifiers to Infants

Four infants in Texas hospitalized with botulism after using pacifiers containing honey

is free, fast, and customized just for you!




Already a member?

Sign In Now »