MTHFR A1298C Polymorphism Not Linked to MTX Outcomes in RA

This article originally appeared here.
Share this content:
<i>MTHFR</i> A1298C Polymorphism Not Linked to MTX Outcomes in RA
MTHFR A1298C Polymorphism Not Linked to MTX Outcomes in RA

FRIDAY, June 2, 2017 (HealthDay News) -- The methylene tetrahydrofolate reductase (MTHFR) gene A1298C polymorphism does not appear to be related to methotrexate (MTX) efficacy or toxicity in patients with rheumatoid arthritis (RA), according to a meta-analysis published online May 25 in the International Journal of Rheumatic Diseases.

Hongqiong Fan, from the First Hospital of Jilin University in Changchun, China, and colleagues conducted a meta-analysis of the existing literature to examine the association of MTHFR gene A1298C polymorphism and MTX outcome in RA. They analyzed 1,325 cases (10 studies) of MTX efficacy and 2,777 cases (18 studies) of MTX toxicity in RA patients.

The researchers observed no significant correlation for MTHFR gene A1298C polymorphism with MTX efficacy or toxicity. In subgroup analysis there was a significant correlation in the South Asian population for MTHFR gene A1298C polymorphism and decreased MTX efficacy (CC versus CA + AA: odds ratio, 0.45). In the partial folate supplementation group there was a correlation for MTHFR gene A1298C polymorphism with decreased MTX efficacy (CC versus CA + AA: odds ratio, 0.43) and toxicity (CC versus CA + AA: odds ratio, 0.40; CC versus AA: odds ratio, 0.38).

"Overall, our meta-analysis suggested no significant effect of MTHFR gene A1298C polymorphism on MTX outcome in RA patients," the authors write. "However, due to several limitations of our meta-analysis, the results should be interpreted cautiously and require further confirmation using high-quality studies."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: More Than 400 Sickened by McDonald's Salads

CDC: More Than 400 Sickened by McDonald's Salads

Multistate outbreak of Cyclosporiasis linked to McDonald's Fresh Express Salad Mix

Jury Awards 289 Million in Case Linking Roundup to Man's Cancer

Jury Awards &#36;289 Million in Case Linking Roundup ...

Case could set a precedent for other lawsuits against Monsanto, the manufacturer of Roundup

Prenatal Tdap Vaccination Not Linked to Autism Risk

Prenatal Tdap Vaccination Not Linked to Autism Risk

No increased risk of autism spectrum disorder in association with prenatal Tdap vaccination

is free, fast, and customized just for you!




Already a member?

Sign In Now »