Mosaic HIV-1 Vaccine Induces Responses in Humans, Monkeys

This article originally appeared here.
Share this content:
Mosaic HIV-1 Vaccine Induces Responses in Humans, Monkeys
Mosaic HIV-1 Vaccine Induces Responses in Humans, Monkeys

THURSDAY, July 12, 2018 (HealthDay News) -- A mosaic adenovirus serotype 26 (Ad26)-based HIV-1 vaccine induces immune responses in humans and rhesus monkeys, according to a study published online July 6 in The Lancet.

Dan H. Barouch, M.D., from Harvard Medical School in Boston, and colleagues conducted a multicenter, randomized, placebo-controlled, phase 1/2a trial involving 393 participants recruited from 12 clinics in east Africa, South Africa, Thailand, and the United States. Healthy HIV-1-uninfected participants who were considered at low risk for HIV-1 infection were randomized to one of seven vaccine combination groups or a placebo group. Four vaccinations were administered over a period of 48 weeks. A parallel study was performed to assess the immunogenicity and protective efficacy of the same Ad26-based mosaic vaccine regimens in rhesus monkeys.

The researchers found that all vaccine regimens demonstrated favorable safety and tolerability. Mild-to-moderate pain at the injection site was the most commonly reported solicited local adverse event. In humans, the mosaic Ad26/Ad26 plus high-dose gp140 boost vaccine was the most immunogenic and elicited Env-specific binding antibody responses, antibody-dependent cellular phagocytosis responses at week 52, and T-cell responses at week 50 (100, 80, and 83 percent, respectively). In rhesus monkeys, Ad26/Ad26 plus gp140 boost induced similar magnitude, durability, and phenotype of immune responses.

"The mosaic Ad26/Ad26 plus gp140 HIV-1 vaccine induced comparable and robust immune responses in humans and rhesus monkeys," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Janssen Vaccines & Prevention, which funded the study.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

8 More U.S. Communities to Be Assessed for PFAS Toxin Exposure

8 More U.S. Communities to Be Assessed for ...

Assessments will lay groundwork for future study of the health effects of perfluoroalkyl, polyfluoroalkyl

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

FDA Advances Regulation to Ensure Sunscreen Safety, Efficacy

Proposed rule will help consumers better understand what the sunscreens they are buying can actually do

U.S. Agencies Probing Johnson  Johnson Over Asbestos in Talc

U.S. Agencies Probing Johnson & Johnson Over Asbestos ...

Company has faced lawsuits linking its body powders with ovarian cancer or mesothelioma

is free, fast, and customized just for you!




Already a member?

Sign In Now »