Modified-FOLFIRINOX Beneficial in Resected Pancreatic Cancer

Share this content:
Modified-FOLFIRINOX Beneficial in Resected Pancreatic Cancer
Modified-FOLFIRINOX Beneficial in Resected Pancreatic Cancer

WEDNESDAY, Dec. 19, 2018 (HealthDay News) -- For patients with resected pancreatic cancer, adjuvant therapy with a modified regimen of chemotherapy with fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX), compared with gemcitabine, results in significantly longer survival, according to a study published in the Dec. 20 issue of the New England Journal of Medicine.

Thierry Conroy, M.D., from the Institut de Cancérologie de Lorraine in Vandoeuvre-lès-Nancy, France, and colleagues randomly assigned 493 patients with resected pancreatic ductal adenocarcinoma to receive either a modified FOLFIRINOX regimen or gemcitabine for 24 weeks.

The researchers found median disease-free survival rates of 21.6 and 12.8 months in the modified-FOLFIRINOX and gemcitabine groups, respectively, during a median follow-up of 33.6 months (stratified hazard ratio for cancer-related event, second cancer, or death, 0.58). At three years, disease-free survival rates were 39.7 and 21.4 percent in the modified-FOLFIRINOX and gemcitabine groups, respectively. Median overall survival was 54.4 and 35.0 months, respectively, in the modified-FOLFIRINOX and gemcitabine groups (stratified hazard ratio for death, 0.64). At three years, overall survival rates were 63.4 and 48.6 percent in the modified-FOLFIRINOX and gemcitabine groups, respectively. Grade 3 or 4 adverse events occurred in 75.9 and 52.9 percent of patients in the modified-FOLFIRINOX and gemcitabine groups, respectively.

"This trial represents the culmination of more than a decade of careful work that initially established FOLFIRINOX as a standard treatment for advanced pancreatic cancer," write the authors of an accompanying editorial.

Several authors disclosed financial ties to the pharmaceutical industry; the study was partially funded by R&D Unicancer, which received a grant from Chugai Pharmaceutical.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »