Microbiome Intervention With Niacin Aids Insulin Sensitivity

Share this content:
Microbiome Intervention With Niacin Aids Insulin Sensitivity
Microbiome Intervention With Niacin Aids Insulin Sensitivity

MONDAY, Dec. 18, 2017 (HealthDay News) -- A targeted microbiome intervention, accomplished through microencapsulated delayed-release niacin, beneficially affects insulin sensitivity in humans, according to a study published online Dec. 6 in Diabetes Care.

Daniela Fangmann, Ph.D., from the University of Kiel in Germany, and colleagues assessed the gut microbiome and niacin in more than 500 participants with different metabolic phenotypes.

The researchers found that reduced α-diversity and Bacteroidetes abundance in the microbiome of obese human subjects were associated with a low dietary niacin intake. In response, the researchers developed delayed-release microcapsules to deliver increasing amounts of nicotinic acid (NA) and nicotinamide (NAM) to the microbiome while preventing systemic resorption. In vivo studies showed that the gut-targeted delayed-release NA, but not NAM, produced a significant increase in the abundance of Bacteroidetes. These favorable microbiome changes were associated with an improvement of biomarkers for systemic insulin sensitivity and metabolic inflammation.

"Targeted microbiome intervention by delayed-release NA might represent a future therapeutic option for prediabetes and type 2 diabetes," the authors write.

One author disclosed financial ties to the pharmaceutical industry, and several are inventors on a patent describing controlled-release formulations for NA and NAM.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Characteristics of Severe Hypoglycemia Identified in T2DM

Characteristics of Severe Hypoglycemia Identified in T2DM

Increased odds of severe hypoglycemia with history of non-severe hypoglycemia, HbA1c <6 percent

Hand-Holding, Stress Ball Don't Cut Anxiety in Skin CA Removal

Hand-Holding, Stress Ball Don't Cut Anxiety in Skin ...

No incremental anxiety reduction versus control in patients during excisional skin cancer surgery

L-Glutamine Reduces Number of Pain Crises in Sickle Cell Disease

<small>L</small>-Glutamine Reduces Number of Pain Crises in Sickle ...

Significantly fewer pain crises, hospitalizations compared with those receiving placebo

is free, fast, and customized just for you!




Already a member?

Sign In Now »