Metabolic Syndrome and Obesity Up Risk of Mortality in CRC

This article originally appeared here.
Share this content:
Metabolic Syndrome and Obesity Up Risk of Mortality in CRC
Metabolic Syndrome and Obesity Up Risk of Mortality in CRC

TUESDAY, Sept. 13, 2016 (HealthDay News) -- For patients with early-stage colorectal cancer (CRC), the presence of metabolic syndrome (MetSyn) and obesity is associated with increased risk of mortality, according to a study published online Sept. 6 in the Journal of Clinical Oncology.

Elizabeth M. Cespedes Feliciano, Sc.D., from Kaiser Permanente Northern California in Oakland, and colleagues studied 2,446 patients with early-stage CRC diagnosed from 2006 to 2011. Participants were classified according to the presence or absence of MetSyn and obesity.

The researchers found that 601 patients died over a median follow-up of six years, 325 as a result of CRC. For overall survival the hazard ratios were 1.45 for obese patients with MetSyn (95 percent confidence interval [CI], 1.12 to 1.82); 1.09 for non-obese with MetSyn (95 percent CI, 0.83 to 1.44); and 1.00 for obese patients without MetSyn (95 percent CI, 0.80 to 1.26), compared to non-obese patients without MetSyn. CRC-related survival was predicted by obesity with MetSyn (hazard ratio, 1.49; 95 percent CI, 1.09 to 2.02). There was an increase in the risk of death with the number of MetSyn components present, which was independent of obesity.

"Patients with early-stage CRC with obesity and MetSyn have worse survival, overall and CRC related," the authors write.

Two authors disclosed financial ties to the biopharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Gender Nonconformity Linked to Students' Mental Distress

Gender Nonconformity Linked to Students' Mental Distress

For male students, gender nonconformity strongly associated with substance use

Participation Up With Online Diabetes Prevention Program

Participation Up With Online Diabetes Prevention Program

But weight loss no different for online, in-person DPP for obese/overweight veterans with prediabetes

Net Benefit of Anticoagulants for A-Fib Varies With Stroke Rate

Net Benefit of Anticoagulants for A-Fib Varies With ...

Benefit of warfarin anticoagulation varies with varying published stroke rates

is free, fast, and customized just for you!




Already a member?

Sign In Now »