Mechanical Ventilation May Alter Diaphragm Muscle Fibers

Share this content:
Mechanical Ventilation May Alter Diaphragm Muscle Fibers
Mechanical Ventilation May Alter Diaphragm Muscle Fibers

TUESDAY, Oct. 9, 2018 (HealthDay News) -- In critically ill patients, mechanical ventilation with positive end-expiratory pressure (PEEP) results in reduced diaphragm fiber length that may make it more difficult to wean patients from mechanical ventilation, according to a study published in the Aug. 15 issue of the American Journal of Respiratory and Critical Care Medicine.

Johan Lindqvist, Ph.D., from the University of Arizona in Tucson, and colleagues studied the structure and function of diaphragm fibers of mechanically ventilated critically ill patients and mechanically ventilated rats with normal and increased titin compliance.

The researchers found that PEEP caused a caudal movement of the diaphragm, both in critically ill patients and in rats; this caudal movement reduced fiber length. In 18-hour mechanically ventilated rats (PEEP of 2.5 cm H2O), diaphragm fibers adapted to the reduced length by absorbing serially linked sarcomeres, the smallest contractile units in muscle (i.e., longitudinal atrophy). Longitudinal atrophy was reduced by increasing the compliance of titin molecules.

"We postulate that longitudinal atrophy, in concert with the aforementioned cross-sectional atrophy, hampers spontaneous breathing trials in critically ill patients: during these efforts, end-expiratory lung volume is reduced, and the shortened diaphragm fibers are stretched to excessive sarcomere lengths," the authors write.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves First Customizable Insulin Pump

FDA Approves First Customizable Insulin Pump

Product works by delivering insulin under the skin at set or variable rates

Sepsis Common in Terminal Hospitalizations, Discharges

Sepsis Common in Terminal Hospitalizations, Discharges

Most common underlying causes of death in sepsis are solid and hematologic cancers, chronic heart disease

Fewer Older Men Assessed, Treated for Osteoporosis

Fewer Older Men Assessed, Treated for Osteoporosis

Fewer older men than women, even with higher risk, undergo DXA screening, 25(OH)D measurement

is free, fast, and customized just for you!




Already a member?

Sign In Now »