Mathematical Model Can Simulate HbA1c Progression in T2DM

Share this content:
Mathematical Model Can Simulate HbA1c Progression in T2DM
Mathematical Model Can Simulate HbA1c Progression in T2DM

TUESDAY, Jan. 10, 2017 (HealthDay News) -- A mathematical model (MM) can simulate hemoglobin A1c (HbA1c) trajectories in type 2 diabetes mellitus (T2DM) models, according to a study published online Dec. 27 in Diabetes, Obesity and Metabolism.

Phil McEwan, Ph.D., from Health Economics and Outcomes Research Ltd. in Cardiff, U.K., and colleagues developed an alternative MM to simulate HbA1c progression in T2DM in contrast to the time-dependent HbA1c trajectories in health economic models, typically informed by the UK Prospective Diabetes Study (UKPDS). They pooled data from 68 eligible studies to develop an alternative MM equation, which was compared with the UKPDS progression equation in illustrative scenarios.

The researchers found that across studies, HbA1c progression was highly heterogeneous and varied with baseline HbA1c, treatment group, and age of patient. They fitted the MM equation with parameters for the mean baseline HbA1c, initial change in HbA1c, and upper quartile of maximum observed HbA1c in the MM equation (8.3, −0.62 and 9.3 percent, respectively). In illustrative scenarios, differences in HbA1c trajectories between the MM and UKPDS approaches affected the timing of therapy escalation.

"The MM represents an alternative approach to simulate HbA1c trajectories in T2DM models, since UKPDS data may not adequately reflect the heterogeneity of HbA1c profiles observed in clinical studies," the authors write. "However, the choice of approach should ultimately be determined by the characteristics of individual patients under consideration, and the clinical face validity of the modeled trajectories."

Several authors were employees of or had financial ties to AstraZeneca, which funded the study.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Dozens of Medical Groups Join Forces to Improve Diagnoses

Dozens of Medical Groups Join Forces to Improve ...

Diagnostic error is the most common cause of medical errors that patients report

HbA1c Variability Is a Strong Predictor of Mortality in T2DM

HbA1c Variability Is a Strong Predictor of Mortality ...

HbA1c variability is a powerful, independent measure, regardless of how it is measured

Pediatric End-Stage Liver Disease Score Underestimates Mortality

Pediatric End-Stage Liver Disease Score Underestimates Mortality

Actual probability of death for patients on liver transplant wait list underestimated by up to 17%

is free, fast, and customized just for you!




Already a member?

Sign In Now »