Maternal GDM Tied to Child's Cardiometabolic Profile

Share this content:
Maternal GDM Tied to Child's Cardiometabolic Profile
Maternal GDM Tied to Child's Cardiometabolic Profile

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Teenage offspring of mothers with gestational diabetes mellitus (GDM) have increased adiposity and an adverse cardiometabolic profile, according to a study published online Oct. 16 in Diabetes Care.

Louise G. Grunnet, Ph.D., from Rigshospitalet in Copenhagen, Denmark, and colleagues compared body composition and associated cardiometabolic traits among 561 9- to 16-year-old offspring of mothers with GDM and 597 control offspring.

The researchers found that offspring of mothers with GDM exhibited higher weight, body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure, and resting heart rate, and lower height, after adjustment for age and sex. Higher total and abdominal fat percentages and lower muscle mass percentages were seen for offspring of mothers with GDM; after correction for offspring BMI, these differences disappeared. Higher fasting plasma glucose, insulin, C-peptide, homeostatic model assessment of insulin resistance (HOMA-IR), and plasma triglyceride levels were seen for offspring of mothers with GDM; they also had reduced fasting plasma high-density lipoprotein cholesterol levels. Compared with control offspring, female offspring of mothers with GDM had earlier onset of puberty. After adjustment for maternal prepregnancy BMI, offspring of mothers with GDM had significantly higher BMI, WHR, fasting glucose, and HOMA-IR; glucose and HOMA-IR remained elevated after correction for maternal and offspring BMI.

"Adolescent offspring of women with GDM show increased adiposity, an adverse cardiometabolic profile, and earlier onset of puberty among girls," the authors write.

One author disclosed financial ties to Novo Nordisk.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Record Number of Tickborne Disease Cases in U.S. Last Year

CDC: Record Number of Tickborne Disease Cases in ...

Most of those cases were Lyme disease

AMA to Collect Data on Suicide Among Doctors-in-Training

AMA to Collect Data on Suicide Among Doctors-in-Training

Administration hopes to identify the systemic factors that contribute to this problem

Under Pressure, JUUL Withdraws Most Flavored E-Cigs From Market

Under Pressure, JUUL Withdraws Most Flavored E-Cigs From ...

Company is also shutting down Facebook and Instagram accounts in the United States

is free, fast, and customized just for you!




Already a member?

Sign In Now »