Magnesium Boosts Environmental Enrichment in Alzheimer's

This article originally appeared here.
Share this content:
Magnesium Boosts Environmental Enrichment in Alzheimer's
Magnesium Boosts Environmental Enrichment in Alzheimer's

THURSDAY, Nov. 30, 2017 (HealthDay News) -- The combination of environmental enrichment (EE) and magnesium-L-threonate (MgT) is more effective than either treatment alone for improving cognition and spatial memory in a mouse model of Alzheimer's disease (AD), according to a study published online Nov. 10 in CNS Neuroscience & Therapeutics.

Ying Huang, from Tsinghua University in Beijing, and colleagues treated APP/PS1 mice with EE, MgT, or the combination of EE and MgT (EM), and compared the effect on memory function.

The researchers found that, compared with either treatment alone, EM was more effective in improving cognition and spatial memory in long-term (12 months; started at age 3 months, before disease manifestation) and short-term (three months; started at age 6 months, after manifestation of disease) treatment. The behavioral improvement corresponded with synaptic contact rescue in the AD mouse brain hippocampal region. EM rescued the activity reduction in two downstream molecules in the N-methyl-D-aspartate receptor (NMDAR) pathway (CaMKII and CREB), but neither single treatment did.

"Environmental enrichment and MgT may synergistically improve recognition and spatial memory by reducing synaptic loss and restoring the NMDAR signaling pathway in AD mice, which suggests that combination of EE and MgT may be a novel therapeutic strategy for AD," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Record Number of Tickborne Disease Cases in U.S. Last Year

CDC: Record Number of Tickborne Disease Cases in ...

Most of those cases were Lyme disease

AMA to Collect Data on Suicide Among Doctors-in-Training

AMA to Collect Data on Suicide Among Doctors-in-Training

Administration hopes to identify the systemic factors that contribute to this problem

Under Pressure, JUUL Withdraws Most Flavored E-Cigs From Market

Under Pressure, JUUL Withdraws Most Flavored E-Cigs From ...

Company is also shutting down Facebook and Instagram accounts in the United States

is free, fast, and customized just for you!




Already a member?

Sign In Now »