Lymphoma Risk Up With Thiopurine, Anti-TNF Tx in IBD

Share this content:
Lymphoma Risk Up With Thiopurine, Anti-TNF Tx in IBD
Lymphoma Risk Up With Thiopurine, Anti-TNF Tx in IBD

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- For patients with inflammatory bowel disease (IBD), the risk of lymphoma is increased with use of thiopurine monotherapy, anti-tumor necrosis factor (TNF) monotherapy, and combination therapy, according to a study published online Nov. 7 in the Journal of the American Medical Association.

Magali Lemaitre, Ph.D., from the Agence Nationale de Súcurité du Médicament et des produits de santé in France, and colleagues examined the risk of lymphoma associated with thiopurines and anti-TNF agents, alone or in combination, for the management of IBD. Data were included for 189,289 patients who were followed for a median of 6.7 years.

The researchers found that during follow-up, 123,069 patients were never exposed and 50,405, 30,294, and 14,229 were exposed to thiopurine monotherapy, anti-TNF monotherapy, and combination therapy, respectively. There were 336 lymphoma cases during follow-up: 220 in unexposed patients, 70 in patients exposed to thiopurine monotherapy, 32 in patients exposed to anti-TNF monotherapy, and 14 in patients exposed to combination therapy. The risk of lymphoma was significantly higher for those exposed to thiopurine monotherapy, anti-TNF monotherapy, or combination therapy versus unexposed patients (adjusted hazard ratios, 2.6, 2.41, and 6.11, respectively). The risk was significantly higher for those exposed to combination therapy versus thiopurine monotherapy or anti-TNF monotherapy (adjusted hazard ratios, 2.35 and 2.53, respectively).

"These findings may inform decisions regarding the benefits and risks of treatment," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Global Prevalence of Insufficient Activity 27.5 Percent

Global Prevalence of Insufficient Activity 27.5 Percent

Levels of insufficient physical activity stable between 2001, 2016; increase seen in high-income countries

HTN Tx Intensification Common Upon Discharge in U.S. Vets

HTN Tx Intensification Common Upon Discharge in U.S. ...

Fourteen percent of older adults admitted to hospital for non-cardiac conditions had intensification of tx

Quarterly Canakinumab Reduces Risk for Gout Attacks

Quarterly Canakinumab Reduces Risk for Gout Attacks

Doesn't affect serum uric acid levels over time, but targets interleukin-1β

is free, fast, and customized just for you!




Already a member?

Sign In Now »