Low-Salt Diet Boosts Efficacy of Antihypertensives

This article originally appeared here.
Share this content:
Low-Salt Diet Boosts Efficacy of Antihypertensives
Low-Salt Diet Boosts Efficacy of Antihypertensives

(HealthDay News) -- A low-salt diet further improves the efficacy of antihypertensive drug regimens, according to a study published May 29 in the Journal of Clinical Pharmacology.

Jing Wang, from The Second Affiliated Hospital of Chongqing Medical University in China, and colleagues randomized 180 patients with mild to moderate primary hypertension to a low-salt diet (LSD; 2.3 g sodium/day) group or a non-low-salt diet (NLSD) group. Each group included three antihypertensive drug regimens: losartan 100 mg; losartan 50 mg/hydrochlorothiazide (HCTZ) 12.5 mg; or irbesartan 150 mg/HCTZ 12.5 mg.

The researchers found that after two months of follow-up there were significant reductions in office blood pressure (BP), 24-hour mean BP, and morning BP in both groups (P ≤ 0.01). Among the three LSD subgroups there were no significant differences. The losartan 50 mg/HCTZ 12.5 mg and the irbesartan 150 mg/HCTZ 12.5 mg subgroups showed similar antihypertensive efficacy in the NLSD group, with significant reductions in BP compared to the losartan 100 mg group. Patients in the LSD had significant BP reductions compared to the NLSD group.

"We concluded that this LSD exerts synergistic BP-reducing effects," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »