Low BMI Linked to Increased Risk of Progression, Death in mCRC

This article originally appeared here.
Share this content:
Low BMI Linked to Increased Risk of Progression, Death in mCRC
Low BMI Linked to Increased Risk of Progression, Death in mCRC

WEDNESDAY, Oct. 28, 2015 (HealthDay News) -- For patients enrolled in metastatic colorectal cancer (mCRC) trials, low body mass index (BMI) is associated with increased risk of progression and death, according to research published online Oct. 26 in the Journal of Clinical Oncology.

Lindsay A. Renfro, Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues examined whether BMI is prognostic or predictive in mCRC using individual data from 21,149 patients enrolled into 25 first-line mCRC trials. Prognostic and predictive effects of BMI were assessed on overall and progression-free survival.

The researchers found that BMI was prognostic for overall and progression-free survival (both P < 0.001), with an L-shaped pattern. The risk of progression and/or death was highest for low BMI, decreased as BMI increased to about 28 kg/m², and then plateaued. Patients with a BMI of 18.5 kg/m² had a 27 percent increased risk of progression and a 50 percent increased risk of death compared with obese patients. Poorer survival was seen in association with low BMI for men versus women (interaction P < 0.001). BMI did not predict treatment effect.

"Possible explanations include negative effects related to cancer cachexia in patients with low BMI, increased drug delivery or selection bias in patients with high BMI, and potential for an interaction between BMI and molecular signaling pathways," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Actigraphy May Overestimate Sleep in ICU Setting

Actigraphy May Overestimate Sleep in ICU Setting

Wide ranges of sleep quality and quantity with use of actigraphy among critically ill patients in ICU

Mortality for Unintentional Drug Poisonings Up Since 1979

Mortality for Unintentional Drug Poisonings Up Since 1979

Trajectory of overall mortality rate smooth; no exponential trajectories in rates for individual drugs

Most Breast Cancer Diagnoses Given Over the Phone

Most Breast Cancer Diagnoses Given Over the Phone

This represents a reversal, with in-person diagnoses more common before 2006

is free, fast, and customized just for you!




Already a member?

Sign In Now »