Long-Term Macrolide Use Linked to Resistant P. Acnes

This article originally appeared here.
Share this content:
Long-Term Macrolide Use Linked to Resistant <i>P. Acnes</i>
Long-Term Macrolide Use Linked to Resistant P. Acnes

MONDAY, Dec. 18, 2017 (HealthDay News) -- Long-term oral macrolide administration may increase macrolide-resistant Propionibacterium acnes, according to a study published online Dec. 13 in the Journal of Dermatology.

Keisuke Nakase, from the Tokyo University of Pharmacy and Life Sciences, and colleagues examined the mutation frequency of macrolide resistance in P. acnes in vitro.

The researchers found that resistant mutants with the 23S rRNA mutation were not isolated when P. acnes mutants were exposed to clarithromycin after being incubated in broth without antimicrobials. After being pre-incubated with 0.03 µg/mL of antimicrobials, the mutants were obtained at the frequency of 10−6. The 23S rRNA mutations A2058G, A2059G, and C2611G were harbored by the resistant mutants. C2611G mutants, which showed resistance to clarithromycin, were obtained 32.1 percent more often when pre-incubated with clarithromycin versus clindamycin. A2058G mutants, which show high-level resistance to clarithromycin and clindamycin, were more often obtained when pre-incubated with clindamycin versus clarithromycin (87.5 percent). There was no difference in the isolation rate of A2059G mutants with either treatment; A2059 mutants showed high-level resistance to macrolides but low-level resistance to clindamycin.

"These results indicate the possibility that long-term use of oral macrolides for acne treatment facilitate the increase of macrolide-resistant P. acnes," the authors write.

The study was partially supported by Pfizer.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

E. Coli Found in Water at Tennessee Ziplining Facility

<i>E. Coli</i> Found in Water at Tennessee Ziplining ...

One visitor to the CLIMB Works Zipline Canopy Tour in Gatlinburg tested positive for norovirus and E. coli

FDA: Illnesses Tied to Fresh Crab Meat Imported From Venezuela

FDA: Illnesses Tied to Fresh Crab Meat Imported ...

Illnesses appear to be caused by Vibrio parahaemolyticus bacteria

FDA Approves First Drug to Treat Smallpox

FDA Approves First Drug to Treat Smallpox

New treatment offers additional option should smallpox ever be used as a bioweapon

is free, fast, and customized just for you!




Already a member?

Sign In Now »