Liraglutide Tied to Significant Weight Loss in Obese

Share this content:
Liraglutide Tied to Significant Weight Loss in Obese
Liraglutide Tied to Significant Weight Loss in Obese

MONDAY, Oct. 2, 2017 (HealthDay News) -- Liraglutide significantly increases weight loss in obese patients, likely by slowing gastric emptying of solids, according to a pilot study published online Sept. 25 in The Lancet Gastroenterology & Hepatology.

Houssam Halawi, M.D., from the Mayo Clinic in Rochester, Minnesota , and colleagues compared the effects of liraglutide and placebo over 16 weeks on gastric motor functions, satiation, satiety, and weight in obese patients (BMI ≥30 kg/m2). Seventeen patients were randomized to the liraglutide group and 18 to the placebo group, and all patients received standardized nutritional and behavioral counseling. Both liraglutide and placebo were increased by 0.6 mg per day each week for five weeks and continued until week 16.

The researchers found that compared with placebo, liraglutide retarded gastric emptying of solids at five (P < 0.0001) and 16 (P = 0.025) weeks, caused significant weight loss at five weeks (P < 0.001) and 16 weeks (P < 0.001), and increased satiation, as measured by lowered maximum tolerated volume, at 16 weeks (P = 0.05) versus the placebo group. From five to 16 weeks of treatment there was tachyphylaxis to the gastric emptying effects of liraglutide. In the treatment group, nausea was the most common adverse event.

"Measurement of gastric emptying (e.g. at 5 weeks of treatment) may be a biomarker of responsiveness and may help select patients for prolonged treatment with this class of medication," conclude the authors.

Some trial medication supplies were supplied by Novo Nordisk.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Wait Times Have Improved in VA Health Care System

Wait Times Have Improved in VA Health Care ...

Wait times similar to private sector in 2014 but shorter overall and in some specialties in 2017

Medication Treatment for Substance Abuse Up in Facilities

Medication Treatment for Substance Abuse Up in Facilities

2007 to 2016 saw increase in use of medication treatment, reaching 36.1 percent in 2016

Mindfulness, Stress Linked to Menopausal Symptoms

Mindfulness, Stress Linked to Menopausal Symptoms

Link between mindfulness and symptoms more robust in women experiencing higher stress

is free, fast, and customized just for you!




Already a member?

Sign In Now »