Liquids in E-Cigarettes Are Heterogeneous, Frequently Toxic

Share this content:
Liquids in E-Cigarettes Are Heterogeneous, Frequently Toxic
Liquids in E-Cigarettes Are Heterogeneous, Frequently Toxic

WEDNESDAY, March 28, 2018 (HealthDay News) -- The e-liquids used in electronic cigarettes (e-cigarettes) are a heterogeneous group, and there is a positive correlation between the number of chemicals contained in the liquid and the likelihood of its toxicity, according to a study published online March 27 in PLOS Biology.

Noting that most of the 7,700 e-liquid flavors available have not been tested for toxicity in the laboratory, M. Flori Sassano, Ph.D., from the University of North Carolina at Chapel Hill, and colleagues developed a three-phase, 384-well, plate-based, high-throughput screening assay to triage and validate the toxicity of multiple e-liquids.

The researchers found that the propylene glycol (PG)/vegetable glycerin (VG) vehicle had an adverse effect on cell viability and that many of the e-liquids were more toxic than PG/VG. All tested e-liquids were analyzed with gas chromatography-mass spectrometry; in non-metric multidimensional scaling analysis, e-liquids were found to be extremely heterogeneous. The more chemicals in an e-liquid, the more toxic it was likely to be; in addition, vanillin was associated with elevated toxicity values. There was a correlation for the concentration of cinnamaldehyde and vanillin, but not triacetin, with toxicity.

"Our data suggest a high-throughput screening approach to evaluate the toxicity of multiple e-liquids is feasible," the authors write. "Such an approach may serve as a roadmap to enable bodies such as the U.S. Food and Drug Administration to better regulate e-liquid composition."

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NIH Panel Will No Longer Review Gene Therapy Experiments

NIH Panel Will No Longer Review Gene Therapy ...

FDA will now assess gene therapy experiments and products as it does with other treatments, drugs

Doctors Remove Contact Lens Embedded in Eyelid for Years

Doctors Remove Contact Lens Embedded in Eyelid for ...

Lens was encapsulated within the upper eyelid soft tissue since childhood eye trauma

CDC: Brucellosis in Dogs Remains a Public Health Risk

CDC: Brucellosis in Dogs Remains a Public Health ...

Infection is under-recognized, may remain a threat without stronger intervention measures

is free, fast, and customized just for you!




Already a member?

Sign In Now »