Leukemia Patients Who Survive Severe GVHD Often Fare Worse

Share this content:
Leukemia Patients Who Survive Severe GVHD Often Fare Worse
Leukemia Patients Who Survive Severe GVHD Often Fare Worse

MONDAY, Oct. 23, 2017 (HealthDay News) -- After hematopoietic stem cell transplantation (HSCT) for acute leukemia, patients who survive severe acute graft-versus-host disease (aGVHD) have a higher risk of developing extensive chronic GVHD (cGVHD) and a higher rate of non-relapse mortality compared with those who did not develop severe aGVHD, according to a study published online Oct. 13 in the Journal of Internal Medicine.

Olle Ringdén, M.D., Ph.D., from the Karolinska Institutet in Sweden, and colleagues analyzed the long-term outcome in patients with acute leukemia who survived for more than six months after HSCT. They compared 1,738 patients alive after severe aGVHD with 21,825 patients who did not develop severe aGVHD (controls).

The researchers found that patients with severe aGVHD had higher non-relapse mortality (NRM) and a higher rate of extensive cGVHD than the controls. While the probability of relapse was significantly lower in the severe aGVHD group, leukemia-free survival (LFS) and overall survival were also significantly lower compared with the controls. For patients with severe aGVHD, five-year LFS was 49 percent versus 61 percent in controls with no or mild GVHD and 59 percent in patients with moderate GVHD.

"This study is a platform for outcome analysis in patients treated with novel therapies for acute GVHD," write the authors.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Wait Times Have Improved in VA Health Care System

Wait Times Have Improved in VA Health Care ...

Wait times similar to private sector in 2014 but shorter overall and in some specialties in 2017

Medication Treatment for Substance Abuse Up in Facilities

Medication Treatment for Substance Abuse Up in Facilities

2007 to 2016 saw increase in use of medication treatment, reaching 36.1 percent in 2016

Mindfulness, Stress Linked to Menopausal Symptoms

Mindfulness, Stress Linked to Menopausal Symptoms

Link between mindfulness and symptoms more robust in women experiencing higher stress

is free, fast, and customized just for you!




Already a member?

Sign In Now »