Late Surfactant Does Not Cut Duration of Ventilation in BPD

This article originally appeared here.
Share this content:
Late Surfactant Does Not Cut Duration of Ventilation in BPD
Late Surfactant Does Not Cut Duration of Ventilation in BPD

MONDAY, Feb. 29, 2016 (HealthDay News) -- Late administration of surfactant does not reduce the duration of ventilation in very preterm neonates with prolonged respiratory distress, according to research published online Feb. 29 in JAMA Pediatrics.

Jean-Michel Hascoët, M.D., of Université de Lorraine in France, and colleagues conducted a double-blind, randomized clinical trial in which 118 neonates, born at less than 33 weeks of gestation, who still needed mechanical ventilation on day 14, were randomly assigned to receive poractant alfa (surfactant) or air. The effect of late surfactant on ventilation duration and respiratory outcomes at 36 weeks' postmenstrual age and at one year postnatal age was examined.

The researchers found that the fraction of inspired oxygen requirements dropped in the surfactant group, but not in the air group, for up to 24 hours after instillation (0.36 versus 0.43; P < 0.005). The combined rate of severe bronchopulmonary dysplasia or death at 36 weeks' postmenstrual age did not differ significantly between the groups (27.1 and 35.6 percent, respectively; P = 0.32). After discharge, fewer surfactant-treated infants needed rehospitalization for respiratory problems (28.3 versus 51.1 percent; P = 0.03); 39.5 and 50 percent, respectively, needed respiratory physical therapy (P = 0.35).

"Late surfactant administration did not alter the early course of bronchopulmonary dysplasia," the authors write. "However, surfactant-treated infants had reduced respiratory morbidity prior to 1 year of age."

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Trends in HIV/AIDS Have Worsened in African-Americans

Trends in HIV/AIDS Have Worsened in African-Americans

Action plan developed for community leaders that can reduce the disparity in HIV/AIDS

cfDNA Screening First for Trisomy 21 Doesn't Cut Miscarriage Rate

cfDNA Screening First for Trisomy 21 Doesn't Cut ...

Invasive testing if positive for trisomy 21 on cfDNA screen compared with immediate invasive testing

HPV Legislation Doesn't Impact Teen Sexual Behaviors

HPV Legislation Doesn't Impact Teen Sexual Behaviors

No substantive or significant associations between HPV legislation and adolescent sexual behaviors

is free, fast, and customized just for you!




Already a member?

Sign In Now »