Kidney Injury Common After Non-Kidney Transplants in Children

This article originally appeared here.
Share this content:
Kidney Injury Common After Non-Kidney Transplants in Children
Kidney Injury Common After Non-Kidney Transplants in Children

MONDAY, Jan. 8, 2018 (HealthDay News) -- In children who receive a non-kidney solid organ transplant, acute kidney injury (AKI) is common in the first year after surgery and is associated with an increased risk of chronic kidney disease (CKD), according to a study published online Dec. 29 in the American Journal of Transplantation.

C. Williams, from the University of Toronto, and colleagues determined the incidence of AKI and CKD among 303 children who received a heart, lung, liver, or multi-organ transplant at the Hospital for Sick Children between 2002 and 2011.

The researchers assessed AKI in the first year after transplant and found that perioperative AKI (within the first week) occurred in 67 percent of children and that AKI after the first week occurred in 36 percent. The highest incidence occurred among lung and multi-organ recipients. CKD developed in 23 children (8 percent) after a median follow-up of 3.4 years. End-stage renal disease developed in fewer than five children, all within 65 days of transplant. There was a significantly greater risk for developing CKD among those with one AKI episode by three months post-transplant, even after adjustment for age, sex, and estimated glomerular filtration rate at transplant (hazard ratio, 2.77).

"AKI is common in the first year post-transplant and associated with significantly greater risk of developing CKD," the authors write. "Close monitoring for kidney disease may allow for earlier implementation of kidney-sparing strategies to decrease risk for progression to CKD."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »