Ketamine Produces Rapid-Onset Antidepressant Action

This article originally appeared here.
Share this content:
Ketamine Produces Rapid-Onset Antidepressant Action
Ketamine Produces Rapid-Onset Antidepressant Action

MONDAY, Jan. 5, 2015 (HealthDay News) -- Ketamine has rapid-onset antidepressant action, although the mechanism of its positive effect is currently unclear, according to research published online Dec. 26 in the Journal of Clinical Pharmacy and Therapeutics.

Noting that the current pharmacotherapeutic treatment of major depressive disorder (MDD) can take weeks to be effective, Erin Drewniany, Pharm.D., from the Temple University School of Pharmacy in Philadelphia, and colleagues examined the role of ketamine as a more rapid-onset antidepressant.

The researchers found that based on recent evidence, ketamine produces rapid-onset antidepressant action. In a review of 29 studies, the response rate for ketamine varied from 25 to 100 percent, although there were no active comparators to control for the subjective effects of ketamine. In a review of studies involving animal models, acute administration of ketamine produced an antidepressant-like effect in rodent models of depression. Ketamine has a broad spectrum of pharmacologic activity, including affinity to the N-methyl-D-aspartate (NMDA) receptor (NDMAR), dopamine D2 receptors, and opioid receptors, as well as inhibition of neuronal reuptake transporters of 5-HT (5-hydroxytryptamine) and norepinephrine.

"Reports of ketamine's efficacy in patients with MDD are supported by extensive preclinical evidence of its efficacy in standard animal models of depression," the authors write. "The mechanism of its positive effect is not known (it is unlikely due to direct NMDAR antagonism, because the NMDAR antagonist memantine is not also antidepressant), but several biochemical mechanisms have been proposed."

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »