January 2019 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for January 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

AHA: Nearly Half of U.S. Adults Have Cardiovascular Disease

THURSDAY, Jan. 31, 2019 (HealthDay News) -- The prevalence of cardiovascular disease (CVD) is 48.0 percent in adults in the United States based on 2013 to 2016 data, according to a report published online Jan. 31 in Circulation.

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E-Cigarettes More Effective for Smoking Cessation

THURSDAY, Jan. 31, 2019 (HealthDay News) -- Electronic cigarettes are more effective for smoking cessation than nicotine replacement therapy, according to a study published online Jan. 30 in the New England Journal of Medicine.

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Small Increase in HbA1c Seen With Switch to Human Insulin in T2DM

THURSDAY, Jan. 31, 2019 (HealthDay News) -- Switching from analogue to human insulin is associated with a small increase in hemoglobin A1c (HbA1c) levels, according to a study published in the Jan. 29 issue of the Journal of the American Medical Association.

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Meta-Analysis: Small Weight Increase Seen for Breakfast Eaters

THURSDAY, Jan. 31, 2019 (HealthDay News) -- Eating breakfast may not be a good strategy for weight loss, according to research published online Jan. 30 in The BMJ.

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FDA Receives an 'F' in Tobacco Prevention Report Card

WEDNESDAY, Jan. 30, 2019 (HealthDay News) -- The U.S. Food and Drug Administration was given an "F" in a new American Lung Association report card evaluating tobacco prevention programs.

CNN Article
State of Tobacco Control

Avoiding Full-Blown Diabetes Cuts Cardiovascular Risk

WEDNESDAY, Jan. 30, 2019 (HealthDay News) -- Midlife increases in fasting glucose (FG) with conversion to diabetes are associated with higher cardiovascular disease (CVD) risk, according to research published online Jan. 7 in Diabetes Care.

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Large Insulin Price Hike to Be Investigated by U.S. Congress

TUESDAY, Jan. 29, 2019 (HealthDay News) -- The soaring cost of insulin will be investigated as the U.S. Congress holds hearings into the high cost of prescription drugs, a lawmaker says.

AP News Article

Few Patients With Type 1 Diabetes Meeting HbA1c Goals

TUESDAY, Jan. 29, 2019 (HealthDay News) -- Only one in five children and adults with type 1 diabetes (T1D) in the United States achieve American Diabetes Association (ADA) goals for glycated hemoglobin (HbA1c), according to a study published online Jan. 18 in Diabetes Technology & Therapeutics.

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Financial Stress, Coronary Heart Disease Linked in African-Americans

MONDAY, Jan. 28, 2019 (HealthDay News) -- Financial stress may be associated with coronary heart disease among African-Americans, according to a study published in the February issue of the American Journal of Preventive Medicine.

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Report IDs Areas Lacking Good Practice in Health Tech Assessment

FRIDAY, Jan. 25, 2019 (HealthDay News) -- In a report published in the January issue of Value in Health, an ISPOR--The Professional Society for Health Economics and Outcomes Research working group indicates the lack of good practices in three areas of health technology assessment (HTA).

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Improved Genetic Risk Score Aids Type 1 Diabetes Classification

FRIDAY, Jan. 25, 2019 (HealthDay News) -- An improved type 1 diabetes (T1D) genetic risk score (GRS), the T1D GRS2, is highly useful for classifying adult incident diabetes type and improving newborn screening, according to a study published in the February issue of Diabetes Care.

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Short Duration Between Dinner, Bed Has No Effect on HbA1c

THURSDAY, Jan. 24, 2019 (HealthDay News) -- Ensuring a short duration between dinner and bedtime has no effect on hemoglobin A1c (HbA1c) levels in middle-aged and older Japanese adults, according to a study published online Jan. 22 in BMJ Nutrition, Prevention & Health.

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Doctors Should Encourage Exercise in Patients With Diabetes, CV Disease

WEDNESDAY, Jan. 23, 2019 (HealthDay News) -- Physicians need to take an active role in prescribing specific exercise training in patients with both type 2 diabetes mellitus and cardiovascular disease, according to a position paper published online Jan. 14 in the European Journal of Preventive Cardiology.

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Endometrial Scratching Does Not Increase Live Birth Rate in IVF

WEDNESDAY, Jan. 23, 2019 (HealthDay News) -- For women undergoing in vitro fertilization (IVF), endometrial scratching by pipelle biopsy between day 3 of the cycle preceding the embryo-transfer cycle and day 3 of the embryo-transfer cycle, does not result in a higher rate of live birth, according to a study published in the Jan. 24 issue of the New England Journal of Medicine.

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Insulin Price More Than Doubled in the United States

WEDNESDAY, Jan. 23, 2019 (HealthDay News) -- Some Americans with type 1 diabetes have cut back on their insulin usage as the cost of the drug nearly doubled over a five-year period.

CBS News Article

Poor Glycemic Control in Type 1 Diabetes Tied to Fracture Risk

TUESDAY, Jan. 22, 2019 (HealthDay News) -- Poor glycemic control is associated with an increased risk for fracture in patients with type 1 diabetes mellitus (T1DM) but not in patients with type 2 diabetes mellitus (T2DM), according to a study published online Jan. 16 in the Journal of Clinical Endocrinology & Metabolism.

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Trained Alert Dogs Can Detect Impending T1DM-Related Events

FRIDAY, Jan. 18, 2019 (HealthDay News) -- Trained alert dogs can help patients with type 1 diabetes regulate their blood glucose levels, according to a study published online Jan. 15 in PLOS ONE.

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Oral Hepatoselective Glucokinase Activator Promising in T2DM

FRIDAY, Jan. 18, 2019 (HealthDay News) -- Use of the oral hepatoselective glucokinase activator (GKA) TTP399 for type 2 diabetes does not cause hypoglycemia and has no detrimental effect on plasma lipids or liver enzymes, according to a study published online Jan. 16 in Science Translational Medicine.

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FDA Panel Has Tie Vote on New Type 1 Diabetes Drug

FRIDAY, Jan. 18, 2019 (HealthDay News) -- A U.S. Food and Drug Administration advisory panel vote on whether to recommend approval of the first oral medication for type 1 diabetes ended in an 8-8 tie Thursday.

The New York Times Article

Radiographic Knee Osteoarthritis Tied to Increased Risk for Death

FRIDAY, Jan. 18, 2019 (HealthDay News) -- Radiographic knee osteoarthritis (RKOA) is associated with an increased risk for mortality from cardiovascular disease (CVD), diabetes, and renal diseases, but self-reported OA is not, according to a study published in the December issue of the International Journal of Epidemiology.

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FDA Down to 5 Weeks of Funding to Review New Drug Applications

THURSDAY, Jan. 17, 2019 (HealthDay News) -- Due to the federal government shutdown, the U.S. Food and Drug Administration has only about five weeks of funding left to review new drug applications, according to Commissioner Scott Gottlieb, M.D.

CNN News Article

Achieving Healthy Diet From Sustainable Food Feasible

THURSDAY, Jan. 17, 2019 (HealthDay News) -- Achieving a healthy diet from sustainable food systems is feasible but will require considerable shifts toward healthy dietary patterns, according to a report from the EAT-Lancet Commission published online Jan. 16 by The Lancet.

EAT-Lancet Commission (subscription or payment may be required)
Editorial (subscription or payment may be required)

Hemochromatosis Mutation Linked to Other Morbidity

THURSDAY, Jan. 17, 2019 (HealthDay News) -- HFE p.C282Y homozygosity, the most common gene mutation causing hereditary hemochromatosis (type 1), is associated with other morbidity in men and women, according to a study published online Jan. 16 in The BMJ.

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Ertugliflozin Seems Safe, Effective for Type 2 Diabetes Treatment

THURSDAY, Jan. 17, 2019 (HealthDay News) -- Ertugliflozin appears safe and effective at improving long-term glycemic control among adults with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin, according to a study published online Jan. 7 in Diabetes, Obesity and Metabolism.

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Adoption of Advanced Health IT Capabilities Inconsistent

WEDNESDAY, Jan. 16, 2019 (HealthDay News) -- Adoption of advanced health information technology (HIT) capabilities is inconsistent across health care systems, with electronic health record (EHR) standardization being the strongest predictor of advanced capabilities, according to a study published in the January issue of the American Journal of Managed Care.

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Replacing Sitting Time With Activity Lowers Mortality Risk

WEDNESDAY, Jan. 16, 2019 (HealthDay News) -- Replacing prolonged sedentary bouts with physical activity reduces mortality risk, but no benefit is seen for replacement with short sedentary bouts, according to a study recently published in the American Journal of Epidemiology.

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Intermittent Fasts Plus Energy Restriction Best for Weight Loss

WEDNESDAY, Jan. 16, 2019 (HealthDay News) -- Intermittent fasting with restricted energy intake may provide better outcomes than daily continuous diet restriction for health and weight loss in obese women, according to a study published in the January issue of Obesity.

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Components of Ideal Cardio Health Cut Diabetes Risk

WEDNESDAY, Jan. 16, 2019 (HealthDay News) -- For individuals with normal fasting glucose but not those with impaired fasting glucose (IFG), a higher number of ideal cardiovascular health (CVH) components correlates with a lower risk for diabetes, according to a study published online Jan. 15 in Diabetologia.

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Study Explores Influence of Genetics, Environment in Disease

TUESDAY, Jan. 15, 2019 (HealthDay News) -- The influence of heritability and environmental factors has been identified for a large number of phenotypes, according to a study published online Jan. 14 in Nature Genetics.

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American College of Physicians Releases 7th Edition of Ethics Manual

TUESDAY, Jan. 15, 2019 (HealthDay News) -- Ethical principles are discussed in an updated Ethics Manual, issued by the American College of Physicians (ACP) and published as a supplement to the Jan. 15 issue of the Annals of Internal Medicine.

American College of Physicians Ethics Manual
Editorial (subscription or payment may be required)

Young-Onset Type 2 Diabetes Tied to Increased Hospitalization Risk

TUESDAY, Jan. 15, 2019 (HealthDay News) -- Adults with young-onset type 2 diabetes (T2D; onset before age 40 years) have an increased hospitalization risk across their life span compared with those with usual-onset T2D, according to a study published online Jan. 15 in the Annals of Internal Medicine.

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Cardiometabolic Risk Up With Tourette, Chronic Tic Disorder

TUESDAY, Jan. 15, 2019 (HealthDay News) -- Patients with Tourette syndrome (TS) or chronic tic disorder (CTD) have an increased risk for developing at least one metabolic or cardiovascular disorder, according to a study published online Jan. 14 in JAMA Neurology.

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Couples Intervention May Aid Partners of Diabetes Patients

MONDAY, Jan. 14, 2019 (HealthDay News) -- Couples interventions have beneficial effects for partners of individuals with type 2 diabetes, according to a study recently published in Diabetic Medicine.

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CDC: Flu Cases Hit 7 Million in the United States

FRIDAY, Jan. 11, 2019 (HealthDay News) -- The flu season is picking up steam, with about 7 million Americans having been struck by a strain of the flu virus, health officials said Friday.

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FluView

Statin Therapy Reduces Risk for Diabetic Retinopathy in T2DM

FRIDAY, Jan. 11, 2019 (HealthDay News) -- For Taiwanese patients with type 2 diabetes and dyslipidemia, statin therapy is associated with a reduced risk for diabetic retinopathy, according to a study published online Jan. 10 in JAMA Ophthalmology.

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High Fiber Intake Tied to Lower Risk for Noncommunicable Disease

FRIDAY, Jan. 11, 2019 (HealthDay News) -- High intake of fiber is associated with a reduced risk for several noncommunicable diseases (NCDs), according to research published online Jan. 10 in the The Lancet.

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Use of Diabetes Monitoring Tests in Primary Care Suboptimal

FRIDAY, Jan. 11, 2019 (HealthDay News) -- Many primary care patients are not given tests recommended for monitoring diabetes, according to a study published in the December issue of Family Medicine and Community Health.

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Prices Still Explain High U.S. Health Care Spending

FRIDAY, Jan. 11, 2019 (HealthDay News) -- The difference in health spending between the United States and other countries is still explained by health care prices, according to a study published in the January issue of Health Affairs.

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Private Equity Acquisition of Physician Practices Discussed

THURSDAY, Jan. 10, 2019 (HealthDay News) -- The phenomenon of private equity acquisition of physician practices is discussed in an Ideas and Opinions piece published online Jan. 8 in the Annals of Internal Medicine.

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Fewer Than 5 Percent of Thyroid Surgery Patients Readmitted

WEDNESDAY, Jan. 9, 2019 (HealthDay News) -- Readmissions after thyroid surgery are relatively low, and more than half occur within a week after discharge, according to a study recently published in Surgery.

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Long Work Hours Tied to Poor Glycemic Control in T2DM

WEDNESDAY, Jan. 9, 2019 (HealthDay News) -- Long work hours (≥60 hours/week) are associated with poor glycemic control in young Japanese men with type 2 diabetes, according to a study published in the January issue of the Journal of Diabetes Investigation.

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Many Female Health Care Workers Live in Poverty

WEDNESDAY, Jan. 9, 2019 (HealthDay News) -- Many U.S. female health care workers, particularly women of color, live in poverty and lack health insurance, according to a study published online Dec. 20 in the American Journal of Public Health.

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Increase in Brand-Name Drug Cost Mainly Due to Existing Drugs

WEDNESDAY, Jan. 9, 2019 (HealthDay News) -- The costs of oral and injectable brand-name drugs increased from 2008 to 2016, with most of the increase due to existing drugs, while new drugs accounted for cost increases in specialty and generic drugs, according to a study published in the January issue of Health Affairs.

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Medical Marketing Has Increased in Past 20 Years

TUESDAY, Jan. 8, 2019 (HealthDay News) -- From 1997 through 2016, there was an increase in medical marketing, especially direct-to-consumer (DTC) advertising, according to research published in the Jan. 1/8 issue of the Journal of the American Medical Association.

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Editor's Note (subscription or payment may be required)

Costs Higher for Those With Comorbid Noncommunicable Diseases

TUESDAY, Jan. 8, 2019 (HealthDay News) -- The costs of having two noncommunicable diseases (NCDs) is generally superadditive, according to a study published online Jan. 8 in PLOS Medicine.

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ACA Coverage Gains Could Erode Without Individual Mandate

TUESDAY, Jan. 8, 2019 (HealthDay News) -- Eliminating the Affordable Care Act's individual mandate penalty is unlikely to destabilize the individual market in California but could roll back coverage gains, according to a study published in the January issue of Health Affairs.

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Childhood Hodgkin Lymphoma Survivors at Risk for Later Cancers

MONDAY, Jan. 7, 2019 (HealthDay News) -- Survivors of childhood Hodgkin lymphoma (HL) remain at increased risk for developing subsequent malignant neoplasms (SMNs), according to research published online Dec. 17 in Cancer.

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Health Benefits of Nonsugar Sweeteners Uncertain

FRIDAY, Jan. 4, 2019 (HealthDay News) -- There is no compelling evidence to indicate health benefits of nonsugar sweetener (NSS) use on a range of health outcomes, according to a review published online Jan. 2 in The BMJ.

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No Increased Fracture Risk With Canagliflozin in Type 2 Diabetes

WEDNESDAY, Jan. 2, 2019 (HealthDay News) -- Canagliflozin is not associated with increased fracture risk versus glucagon-like peptide-1 (GLP-1) agonists for middle-aged patients with type 2 diabetes, according to a study published online Jan. 1 in the Annals of Internal Medicine.

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