Inverse Link for Plasma 25(OH)D Concentration, Risk of T2DM

Share this content:
Inverse Link for Plasma 25(OH)D Concentration, Risk of T2DM
Inverse Link for Plasma 25(OH)D Concentration, Risk of T2DM

WEDNESDAY, May 23, 2018 (HealthDay News) -- There is an inverse association for plasma 25-hydroxyvitamin D (25[OH]D) concentration with diabetes risk, according to a study published online April 19 in PLOS ONE.

Sue K. Park, M.D., Ph.D., from the Seoul National University College of Medicine in South Korea, and colleagues performed a cohort study involving 903 adults who were known to be free of diabetes or prediabetes during a visit conducted in 1997 to 1999. Plasma 25(OH)D was measured, and fasting plasma glucose and oral glucose tolerance testing were conducted. Patients were followed through 2009.

The researchers identified 47 cases of diabetes and 337 cases of prediabetes. There was a correlation for higher 25(OH)D concentrations (>30 ng/mL) with lower hazard ratios for diabetes (hazard ratios, 0.31 for 30 to 39 ng/mL, 0.29 for 40 to 49 ng/mL, and 0.19 for >50 ng/mL compared with <30 ng/mL). An inverse dose-response gradient was seen between 25(OH)D concentration and risk of diabetes (P for trend 0.005). The hazard ratio was 0.64 in association with each 10 ng/mL higher 25(OH)D concentration. There was a more weak inverse association for 25(OH)D concentrations with prediabetes risk; however, the trend was not significant.

"Further research is needed on whether high 25(OH)D might prevent type 2 diabetes or transition of prediabetes to diabetes," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »