Infection Risk Up Before Chronic Immune Thrombocytopenia

This article originally appeared here.
Share this content:
Infection Risk Up Before Chronic Immune Thrombocytopenia
Infection Risk Up Before Chronic Immune Thrombocytopenia

WEDNESDAY, Feb. 3, 2016 (HealthDay News) -- The incidence of primary chronic immune thrombocytopenia (cITP) is 2.30/100,000 person-years, and incidence is associated with increased risk of infections within the five years before cITP diagnosis, according to a study published online Jan. 21 in the Journal of Thrombosis and Haemostasis.

Charlotta Ekstrand, from the Karolinska Institutet in Stockholm, and colleagues examined the correlation of cITP with infection before diagnosis. Data were included for 1,087 adults with primary cITP identified from the Swedish Patient Register between 2006 and 2012. Using rates from the general population, the authors estimated the standardized incidence ratios (SIRs) as a measure of relative risk.

The researchers found that cITP incidence was 2.30 per 100,000 person-years. There was a correlation for cITP with elevated risk of serious infections requiring inpatient or outpatient care within five years prior to cITP diagnosis (SIR, 8.74). Candidiasis, viral infection of unspecified site, and acute upper respiratory infections had higher magnitude SIRs. The SIR for anti-infective drugs was 1.37; the highest SIRs were seen for amoxicillin, macrolides, nitrofurantoin, and antivirals.

"The findings indicate that infection is not only related to the immunomodulation treatment but also to the disease itself," the authors write.

The Centre for Pharmacology and Epidemiology unit at the Karolinska Institutet collaborates with another university that receives funding from Amgen in the form of research grants.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Zika, West Nile Cases Reported in Alabama

Zika, West Nile Cases Reported in Alabama

State health officials note that Zika hasn't been transmitted locally

TBI Linked to Increased Suicide Risk

TBI Linked to Increased Suicide Risk

Increased suicide risk with one, two, and three or more medical contacts for traumatic brain injury

Triple Combo Blood Pressure Pill Can Improve BP Control

Triple Combo Blood Pressure Pill Can Improve BP ...

Proportion achieving target BP increased with use of triple combo pill versus usual care at six months

is free, fast, and customized just for you!




Already a member?

Sign In Now »