Increasing Severity of Airflow Limitation Linked to Lung CA Risk

Share this content:
Increasing Severity of Airflow Limitation Linked to Lung CA Risk
Increasing Severity of Airflow Limitation Linked to Lung CA Risk

THURSDAY, Jan. 19, 2017 (HealthDay News) -- For older heavy cigarette smokers, the severity of airflow limitation is associated with increasing lung cancer risk, according to a study published online Jan. 11 in the Annals of the American Thoracic Society.

Raewyn J. Hopkins, M.P.H., from the University of Auckland in New Zealand, and colleagues examined the correlation between the severity of airflow limitation and lung cancer risk in a prospective study of older heavy smokers from the American College of Radiology Imaging Network sub-cohort of the National Lung Screening Trial (NLST-ACRIN). Airflow limitation was classified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grade 1 to 4.

The researchers found that 35 and 65 percent of the NLST-ACRIN cohort of 18,473 screening participants had airflow limitation and no airflow limitation, respectively. Seven hundred fifty-eight lung cancer cases were prospectively identified. Lung cancer incidence was 3.78/1,000 person-years for those with no airflow limitation. For those with airflow limitation, incidence rates increased in a simple linear relationship: 6.27, 7.86, 10.71, and 13.25/1,000 person-years for GOLD 1, GOLD 2, GOLD 3, and GOLD 4, respectively. Compared with the reference group, all relationships were significant (P ≤ 0.0001).

"In a large prospective study of high-risk cigarette smokers, we report a strong linear relationship between increasing severity of airflow limitation and risk of lung cancer," the authors write.

The study was funded by a grant from Johnson & Johnson.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »