Increased Levels of Human Herpesvirus ID'd in Alzheimer's

Share this content:
Increased Levels of Human Herpesvirus ID'd in Alzheimer's
Increased Levels of Human Herpesvirus ID'd in Alzheimer's

MONDAY, July 30, 2018 (HealthDay News) -- Subjects with Alzheimer's disease have increased levels of two strains of human herpesvirus, according to a study published online July 11 in Neuron.

Ben Readhead, M.B.B.S., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues constructed multiscale networks of the late-onset Alzheimer's disease-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions using tissue from human postmortem samples.

The researchers found that, compared with controls, subjects with Alzheimer's disease had increased human herpesvirus 6A (HHV-6A) and HHV-7. In two additional, independent, and geographically dispersed cohorts, these results were replicated. Regulatory relationships were seen linking viral abundance and modulators of APP metabolism; HHV-6A induced APBB2, APPBP2, BIN1, BACE1, CLU, PICALM, and PSEN1.

"This study represents a significant advancement in our understanding of the plausibility of the pathogen hypothesis of Alzheimer's," a coauthor said in a statement. "If it becomes evident that specific viral species directly contribute to an individual's risk of developing Alzheimer's or their rate of progression once diagnosed, then this would offer a new conceptual framework for understanding the emergence and evolution of Alzheimer's at individual, as well as population, levels."

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA: Gout Drug Uloric Increases Risk of Death

FDA: Gout Drug Uloric Increases Risk of Death

Medication is associated with increased risk of heart-related death and death from all causes

Since Early 2000s, Overdose Death Rates Are Highest in U.S.

Since Early 2000s, Overdose Death Rates Are Highest ...

U.S. was not an outlier in terms of drug overdose mortality prior to the early 2000s

National Health Spending Set to Increase 5.5 Percent Annually

National Health Spending Set to Increase 5.5 Percent ...

Long-observed demographic and economic factors expected to drive growth in health spending

is free, fast, and customized just for you!




Already a member?

Sign In Now »