Incidence of Statin-Associated T2DM Relatively Low

Share this content:
Incidence of Statin-Associated T2DM Relatively Low
Incidence of Statin-Associated T2DM Relatively Low

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For patients without diabetes, the incidence of statin-associated type 2 diabetes mellitus (T2DM) is relatively low, according to research published in the Nov. 1 issue of The American Journal of Cardiology.

Payal Kohli, M.D., from Kaiser Permanente in Denver, and colleagues conducted a retrospective analysis of data from subjects without diabetes in the Treating to New Targets (TNT) and Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trials to identify increased risk of statin-associated T2DM. Participants were subdivided into four groups: normal fasting glucose (NFG) and triglyceride (TG) ≤1.7 mmol/L; NFG and TG >1.7 mmol/L; prediabetes mellitus (PreDM) and TG ≤1.7 mmol/L; and PreDM and TG >1.7 mmol/L. Comparable groupings were created by substituting body mass index (BMI) values for TG concentration (<27.0 and ≥27.0 kg/m²).

The researchers found that 8.2 percent of the total population developed incident T2DM. There was variation in T2DM event rates (statin or placebo), from a low of 2.8 percent/3.2 percent (NFG and TG ≤1.7 mmol/L) to a high of 22.8 percent/7.6 percent (PreDM and TG >1.7 mmol/L); the values were intermediate for only elevated TG >1.7 mmol/L (5.2 percent /4.3 percent) or only PreDM (12.8 percent/7.6 percent). The differences were comparable with BMI values.

"These data suggest that the diabetogenic impact of statin treatment is relatively modest in general," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Pfizer, which funded the TNT and SPARCL clinical trials.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Gender Nonconformity Linked to Students' Mental Distress

Gender Nonconformity Linked to Students' Mental Distress

For male students, gender nonconformity strongly associated with substance use

Participation Up With Online Diabetes Prevention Program

Participation Up With Online Diabetes Prevention Program

But weight loss no different for online, in-person DPP for obese/overweight veterans with prediabetes

Net Benefit of Anticoagulants for A-Fib Varies With Stroke Rate

Net Benefit of Anticoagulants for A-Fib Varies With ...

Benefit of warfarin anticoagulation varies with varying published stroke rates

is free, fast, and customized just for you!




Already a member?

Sign In Now »