Improved Long-Term Pregnancy Outcomes for Goserelin + Chemo

Share this content:
Improved Long-Term Pregnancy Outcomes for Goserelin + Chemo
Improved Long-Term Pregnancy Outcomes for Goserelin + Chemo

THURSDAY, Nov. 8, 2018 (HealthDay News) -- For premenopausal women with stage I to IIIA estrogen receptor-negative, progesterone receptor-negative breast cancer, goserelin plus chemotherapy is associated with an increased likelihood of becoming pregnant without an increased risk for adverse effects, according to a study published online Oct. 29 in the Journal of the National Cancer Institute.

Halle C.F. Moore, M.D., from the Cleveland Clinic Foundation, and colleagues examined long-term pregnancy and disease-related outcomes for patients in S0230/POEMS, which enrolled premenopausal women with stage I to IIIA estrogen receptor-negative, progesterone receptor-negative breast cancer. Participants were randomly assigned to standard chemotherapy with or without goserelin. A total of 105 patients in the chemotherapy + goserelin arm and 113 in the chemotherapy arm were evaluable.

The researchers found that at least one pregnancy was reported by more patients in the chemotherapy + goserelin arm versus the chemotherapy arm (five-year cumulative incidence, 23.1 versus 12.2 percent, respectively; odds ratio, 2.34; 95 percent confidence interval, 1.07 to 5.11; P = 0.03). There were non-statistically significant improvements in disease-free and overall survival with randomization to goserelin + chemotherapy (hazard ratios, 0.55 [95 percent confidence interval, 0.27 to 1.1; P = 0.09] and 0.45 [95 percent confidence interval, 0.19 to 1.04; P = 0.06], respectively).

"Our final results show a means to improve quality of life for young women with hormone-receptor negative breast cancer," Moore said in a statement. "If they want to be mothers, they can improve their chances safely and effectively."

Several authors disclosed financial ties to pharmaceutical companies, including AstraZeneca, which partially funded the study and provided the study drug.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA: Gout Drug Uloric Increases Risk of Death

FDA: Gout Drug Uloric Increases Risk of Death

Medication is associated with increased risk of heart-related death and death from all causes

Since Early 2000s, Overdose Death Rates Are Highest in U.S.

Since Early 2000s, Overdose Death Rates Are Highest ...

U.S. was not an outlier in terms of drug overdose mortality prior to the early 2000s

National Health Spending Set to Increase 5.5 Percent Annually

National Health Spending Set to Increase 5.5 Percent ...

Long-observed demographic and economic factors expected to drive growth in health spending

is free, fast, and customized just for you!




Already a member?

Sign In Now »