Impact of T2DM Meds on Heart Failure Hospitalization Explored

This article originally appeared here.
Share this content:
Impact of T2DM Meds on Heart Failure Hospitalization Explored
Impact of T2DM Meds on Heart Failure Hospitalization Explored

TUESDAY, Jan. 19, 2016 (HealthDay News) -- For patients with type 2 diabetes, there is no association between hospitalization for heart failure and treatment with dipeptidyl peptidase-4 inhibitors (DPP-4is) versus sulfonylureas (SUs) or treatment with saxagliptin versus sitagliptin, according to a study published online Jan. 6 in Diabetes Care.

Alex Z. Fu, Ph.D., from the Georgetown University Medical Center in Washington, D.C., and colleagues conducted an observational study using a U.S. insurance claims database. They examined the correlation between hospitalization for heart failure and treatment with DPP-4i versus SU (218,556 patients), and treatment with saxagliptin versus sitagliptin (112,888 patients).

The researchers found that for DPP-4i versus SU (reference), the hazard ratios for hospitalization for heart failure were 0.95 (95 percent confidence interval [CI], 0.78 to 1.15; P = 0.580) for patients with baseline cardiovascular disease (CVD) and 0.59 (95 percent CI, 0.38 to 0.89; P = 0.013) for patients without baseline CVD. For saxagliptin versus sitagliptin (reference), the hazard ratios for hospitalization for heart failure were 0.95 (95 percent CI, 0.70 to 1.28; P = 0.712) for patients with baseline CVD and 0.99 (95 percent CI, 0.56 to 1.75; P = 0.972) for patients without baseline CVD.

"In patients with type 2 diabetes, there was no association between hospitalization for heart failure, or other selected cardiovascular outcomes, and treatment with a DPP-4i relative to SU or treatment with saxagliptin relative to sitagliptin," the authors write.

Several authors disclosed financial ties to Truven Health Analytics and pharmaceutical companies, including AstraZeneca, which funded the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ground Beef Recalled After E. Coli Outbreak

Ground Beef Recalled After <i>E. Coli</i> Outbreak

Beef was produced and packaged at Cargill Meat Solutions in Fort Morgan, Colo.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

Alzheimer's disease and related dementias burden is expected to increase to 3.3 percent in 2060

Long-Term Outcomes of Breast Implants Explored

Long-Term Outcomes of Breast Implants Explored

Higher rates of Sjogren syndrome, scleroderma, RA, stillbirth, melanoma for silicone implants

is free, fast, and customized just for you!




Already a member?

Sign In Now »