Immune Checkpoint Inhibitor Endocrine Dysfunction Explored

Share this content:
Immune Checkpoint Inhibitor Endocrine Dysfunction Explored
Immune Checkpoint Inhibitor Endocrine Dysfunction Explored

THURSDAY, Sept. 28, 2017 (HealthDay News) -- Patients receiving immune checkpoint inhibitor (ICI) regimens may experience endocrine dysfunction, with increased risk of thyroid dysfunction and hypophysitis for patients on combination therapy, according to a review published online Sept. 28 in JAMA Oncology.

Romualdo Barroso-Sousa, M.D., Ph.D., from the Dana-Farber Cancer Institute in Boston, and colleagues examined endocrine adverse events using data from 38 randomized clinical trials assessing use of ICIs for advanced solid tumors, with 7,551 patients eligible for meta-analysis. The regimens were categorized as monotherapy with a programmed cell death protein 1 (PD-1) inhibitor, a cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor, a programmed cell death 1 ligand 1 (PD-L1) inhibitor, and combination therapy with PD-1 plus CTLA-4 inhibitors.

The researchers found that patients receiving combination therapy had the highest incidence of both hypothyroidism and hyperthyroidism. Compared with patients on ipilimumab, patients on the combination regimen were significantly more likely to experience hypothyroidism and hyperthyroidism (odds ratios, 3.81 and 4.27). A significantly greater risk of hyperthyroidism but not hypothyroidism was seen with PD-1 versus PD-L1 inhibitors (odds ratio, 5.36). Patients receiving PD-1 inhibitors were less likely that those receiving ipilimumab to experience hypophysitis (odds ratio, 0.29), while the likelihood was increased for those who received combination therapy (odds ratio, 2.2).

"Our study provides more precise data on the incidence of endocrine dysfunctions among patients receiving ICI regimens," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Educational phone calls with nurses promote shared decision making in care

Early PT Linked to Less Opioid Use in Musculoskeletal Pain

Early PT Linked to Less Opioid Use in ...

For opioid-naive patients, early physical therapy tied to less opioid use in shoulder, neck, knee, back pain

Emotional Stress of Holidays Can Trigger Heart Attacks

Emotional Stress of Holidays Can Trigger Heart Attacks

Higher risk seen on Christmas Eve, particularly in older adults with diabetes, heart disease

is free, fast, and customized just for you!




Already a member?

Sign In Now »