IC Nicardipine Promising for Tx of Spontaneous Coronary Slow-Flow

Share this content:
IC Nicardipine Promising for Tx of Spontaneous Coronary Slow-Flow
IC Nicardipine Promising for Tx of Spontaneous Coronary Slow-Flow

WEDNESDAY, Jan. 9, 2019 (HealthDay News) -- Intracoronary (IC) administration of nicardipine seems to be highly effective in reversing spontaneous coronary slow-flow (CSF), according to a study published online Dec. 15 in the Journal of Invasive Cardiology.

Hetal H. Mehta, M.D., from Thomas Jefferson University Hospital in Philadelphia, and colleagues evaluated the effect of IC nicardipine in 30 patients (22 men; mean age, 54 years) with CSF (defined as spontaneously delayed flow [<TIMI 3] during diagnostic coronary angiography in the absence of obstructive epicardial coronary artery disease or other conditions). A 200-microgram IC bolus of nicardipine was administered after which repeat angiography was performed.

The researchers found CSF in 49 vessels at baseline. TIMI frame count (TFC) was prolonged (>27) in 68 of the 90 vessels. Administration of IC nicardipine produced markedly accelerated coronary filling, which was verified by TFC analysis. TFC was 47 before nicardipine versus 15 after. After nicardipine treatment, all vessels showed TIMI 3 flow and TFC <28.

"These findings implicate microvascular spasm in the pathogenesis of CSF," the authors write. "Future studies of oral calcium-channel blockers in the long-term management of CSF are needed."

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Wait Times Have Improved in VA Health Care System

Wait Times Have Improved in VA Health Care ...

Wait times similar to private sector in 2014 but shorter overall and in some specialties in 2017

Medication Treatment for Substance Abuse Up in Facilities

Medication Treatment for Substance Abuse Up in Facilities

2007 to 2016 saw increase in use of medication treatment, reaching 36.1 percent in 2016

Mindfulness, Stress Linked to Menopausal Symptoms

Mindfulness, Stress Linked to Menopausal Symptoms

Link between mindfulness and symptoms more robust in women experiencing higher stress

is free, fast, and customized just for you!




Already a member?

Sign In Now »