Ibuprofen May Harm Fetal Ovaries During First Trimester

Share this content:
Ibuprofen May Harm Fetal Ovaries During First Trimester
Ibuprofen May Harm Fetal Ovaries During First Trimester

FRIDAY, Feb. 2, 2018 (HealthDay News) -- Exposure to ibuprofen is harmful to developing human fetal ovaries ex vivo in the first trimester, according to a study published online Feb. 2 in Human Reproduction.

Sabrina Leverrier-Penna, Ph.D., from the Institute of Research in Health, Environment, and Work in Rennes, France, and colleagues obtained organotypic cultures of human ovaries from fetuses between seven and 12 developmental weeks and exposed the explants to ibuprofen at 1 to 100 µM for two, four, or seven days. A control culture was included for each individual and compared to its treated counterpart. Data from 185 individual samples were included.

The researchers found that human ovarian explants exposed to 10 and 100 µM ibuprofen showed reduced cell number, decreased cell proliferation, increased apoptosis, and a dramatic loss of germ cell number, regardless of the gestational age of the fetus. After seven days of exposure to 10 µM ibuprofen, significant effects were observed. Apoptosis was observed as early as two days after treatment at this concentration as well as a reduction in M2A-positive germ cell number. After five days of drug withdrawal, the deleterious effects of ibuprofen were not fully rescued.

"These findings deserve to be considered in light of the present recommendations about ibuprofen consumption pregnancy," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »