Hypoglycemia, Atherosclerosis Progression Link Explored

This article originally appeared here.
Share this content:
Hypoglycemia, Atherosclerosis Progression Link Explored
Hypoglycemia, Atherosclerosis Progression Link Explored

MONDAY, Jan. 25, 2016 (HealthDay News) -- In the Veterans Affairs Diabetes Trial, hypoglycemia was associated with coronary artery calcium (CAC) progression only in the standard therapy group (versus intensive therapy), according to research published online Jan. 19 in Diabetes Care.

Aramesh Saremi, M.D., from the Phoenix VA Health Care System, and colleagues examined the correlation between serious hypoglycemia (severe episodes with loss of consciousness or requiring assistance, or documented glucose <50 mg/dL) and progression of atherosclerosis. The correlation was assessed in 197 participants in a substudy of the Veterans Affairs Diabetes Trial.

The researcher found that 97 patients reported severe hypoglycemia or glucose <50 mg/dL (23 and 74 patients, respectively) during an average follow-up of 4.5 years between computed tomography scans. Serious hypoglycemia occurred more often in the intensive therapy versus the standard treatment group (74 versus 21 percent; P < 0.01). In the entire cohort there was no correlation between serious hypoglycemia with progression of CAC, but there was a significant interaction between serious hypoglycemia and treatment (P < 0.01). CAC progression was about 50 percent greater for participants with serious hypoglycemia in the standard therapy group, but not in the intensive therapy group, compared to those without serious hypoglycemia (median, 11.15 versus 5.4 mm³; P = 0.02).

"Despite a higher frequency of serious hypoglycemia in the intensive therapy group, serious hypoglycemia was associated with progression of CAC in only the standard therapy group," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »