Higher Positive Cardiomyopathy Genetic Detection Rates for Whites

Share this content:
Higher Positive Cardiomyopathy Genetic Detection Rates for Whites
Higher Positive Cardiomyopathy Genetic Detection Rates for Whites

MONDAY, March 5, 2018 (HealthDay News) -- Compared with underrepresented minorities, white individuals have significantly higher positive detection rates and lower rates of inconclusive results on cardiomyopathy genetic testing, according to a study published online Feb. 28 in JAMA Cardiology.

Latrice G. Landry, Ph.D., from the U.S. Food and Drug Administration in Silver Spring, Md., and Heidi L. Rehm, Ph.D., from Brigham and Women's Hospital in Boston, conducted a cross-sectional analysis of the genetic panel test results for 5,729 probands with a suspected diagnosis or family history of cardiomyopathy who had been referred for testing. The results were stratified into three categories: white (79.2 percent), Asian (6.1 percent), and underrepresented minorities (14.7 percent).

The researchers found that positive detection occurred in 29 percent of white individuals compared with 18.4 and 25 percent of underrepresented minorities and Asians, respectively (P < 0.001 and P = 0.12, respectively). Inconclusive results were seen in 24.6 percent of whites compared with 39.8 and 39.2 percent of underrepresented minorities and Asians, respectively (both P < 0.001).

"This clear disparity warrants further study to understand the gaps in usefulness, which may derive from a lack of clinical testing and research in underrepresented minority populations, in the hopes of improving genetic testing outcomes for cardiomyopathy in nonwhite groups," the authors write.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

California Lawsuit Claims AbbVie Paid Doctors to Prescribe Humira

California Lawsuit Claims AbbVie Paid Doctors to Prescribe ...

Claims physicians prescribed Humira because of financial kickbacks, not as best drug for patient

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-Directed IV Remifentanil Cuts Epidural Conversions

Patient-controlled remifentanil reduces proportion of conversions versus intramuscular pethidine

Pediatricians Have Role in Supporting Transgender Youth

Pediatricians Have Role in Supporting Transgender Youth

Recommendations developed for comprehensive care for youth identifying as transgender, gender diverse

is free, fast, and customized just for you!




Already a member?

Sign In Now »