High Prevalence of Allergic Sensitization in Pediatric Asthma

This article originally appeared here.
Share this content:
High Prevalence of Allergic Sensitization in Pediatric Asthma
High Prevalence of Allergic Sensitization in Pediatric Asthma

THURSDAY, Sept. 22, 2016 (HealthDay News) -- Among children with persistent asthma, the prevalence of allergic sensitization is high, according to a study published online Sept. 17 in Allergy.

Annica Önell, Ph.D., from Microtest Dx in London, and colleagues examined the accuracy of and information obtained by two microarray platforms applied on a pediatric asthma cohort. Seventy-one children from a Swedish study were recruited, of whom 40 and 31 had severe and controlled asthma, respectively. Participants were assessed for allergic sensitization by two microarray systems and by two standard diagnostic methods.

The researchers observed a high prevalence of allergic sensitization in the cohort. Independently of the methods compared, the pairwise concordance between two methods was 90 to 92 percent. The sensitivity and specificity of the four methods against doctor's diagnosis was 0.77 to 0.88 and 0.97 to 0.99, respectively. In 47 percent of the sensitized children, microarray methods provided new information compared with results obtained by standard diagnostic methods.

"The high prevalence of food and respiratory sensitization supports the clinical guideline recommendation that allergies should be evaluated in all children with suspected asthma," the authors write. "The microarray platforms studied here demonstrated acceptable accuracy and provided refined immunoglobulin E characterization in 47 percent of the patients compared to standard extract-based methods."

Three authors are employees of Microtest Dx, which makes one of the microarray systems used in the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Critics Demand Stop to 'Guinea Pig' Sepsis Clinical Trial

Critics Demand Stop to 'Guinea Pig' Sepsis Clinical ...

Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis

Education Can Up Emotional Intelligence in Residents

Education Can Up Emotional Intelligence in Residents

Increase in total EI median scores, stress management composite score after intervention

Cancer-Related Gene Variations Frequently Reclassified

Cancer-Related Gene Variations Frequently Reclassified

24.9 percent of variants of uncertain significance were reclassified at a single commercial laboratory

is free, fast, and customized just for you!




Already a member?

Sign In Now »