High Patient Burden With Moderate-to-Severe Atopic Dermatitis

Share this content:
High Patient Burden With Moderate-to-Severe Atopic Dermatitis
High Patient Burden With Moderate-to-Severe Atopic Dermatitis

THURSDAY, July 5, 2018 (HealthDay News) -- Patients with moderate/severe atopic dermatitis (AD) have higher patient-reported burden than those with mild AD, regardless of disease control, according to a study published online July 3 in JAMA Dermatology.

Eric L. Simpson, M.D., from the Oregon Health & Science University in Portland, and colleagues characterized the patient-reported burden of AD in a cross-sectional study using data from six academic medical centers. Using the Patient-Oriented Scoring Atopic Dermatitis, they stratified 1,519 adults with AD by AD severity as mild or moderate/severe. Those with moderate/severe disease using systemic immunomodulators/phototherapy were further stratified according to disease control.

The researchers found that the 830 patients with moderate/severe AD reported more severe itching and pain, greater adverse effects on sleep, higher prevalence of anxiety and depression (50.2 versus 27.3 percent), and greater health-related quality-of-life impairment compared to mild AD (689 patients). For patients with moderate/severe AD, higher burdens of itch and sleeping symptoms were reported for those with inadequate disease control despite treatment with systemic immunomodulators or phototherapy versus those with controlled disease; this included more days per week with itchy skin (5.7 versus 2.7) and higher proportions with itch duration greater than half a day (22.8 versus 2.9 percent).

"Regardless of disease control, the burden of moderate/severe AD was higher than mild AD, suggesting a need for more effective therapies for moderate/severe disease," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Regeneron Pharmaceuticals and Sanofi, which funded the study.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »