Hemorrhage Risk Up in A-Fib Patients on Dabigatran, Statins

This article originally appeared here.
Share this content:
Hemorrhage Risk Up in A-Fib Patients on Dabigatran, Statins
Hemorrhage Risk Up in A-Fib Patients on Dabigatran, Statins

MONDAY, Nov. 21, 2016 (HealthDay News) -- Combining dabigatran with certain statin medications could raise the odds for major hemorrhage in patients with atrial fibrillation, according to a study published online Nov. 21 in CMAJ, the journal of the Canadian Medical Association.

Tony Antoniou, Ph.D., a pharmacist at St. Michael's Hospital in Toronto, and colleagues tracked outcomes for 45,991 patients ages 65 and older. All had atrial fibrillation and took dabigatran to reduce their risk of stroke.

The researchers found that patients who also took either lovastatin or simvastatin had a 40 percent higher risk of major hemorrhage than those who took other statins (adjusted odds ratio, 1.46).

"We found that among older patients taking dabigatran etexilate, simvastatin and lovastatin were not associated with an increased risk of stroke relative to other statins, suggesting that carboxylesterase inhibition is of little clinical relevance in this setting. However, this finding may reflect a lack of power for detecting an association," the authors write. "In contrast, simvastatin and lovastatin were associated with an increased risk of major hemorrhage in these patients, which may reflect increased dabigatran absorption as a result of P-glycoprotein inhibition. Clinicians should consider avoiding simvastatin and lovastatin in older patients receiving dabigatran etexilate who require statin therapy."

One author disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Dozens of Medical Groups Join Forces to Improve Diagnoses

Dozens of Medical Groups Join Forces to Improve ...

Diagnostic error is the most common cause of medical errors that patients report

HbA1c Variability Is a Strong Predictor of Mortality in T2DM

HbA1c Variability Is a Strong Predictor of Mortality ...

HbA1c variability is a powerful, independent measure, regardless of how it is measured

Pediatric End-Stage Liver Disease Score Underestimates Mortality

Pediatric End-Stage Liver Disease Score Underestimates Mortality

Actual probability of death for patients on liver transplant wait list underestimated by up to 17%

is free, fast, and customized just for you!




Already a member?

Sign In Now »